Estradiol/Norethindrone (By mouth)
es-tra-DYE-ol, nor-ETH-in-drone AS-e-tate
Uses of This Medicine
Estradiol and norethindrone combination is used to treat moderate to severe hot flashes and other symptoms of menopause. It is also used to treat changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. This medicine is also used to treat certain conditions in women before menopause if their ovaries do not make enough estrogens naturally, and prevent osteoporosis after menopause.
This medicine is a combination of two hormones: an estrogen hormone (estradiol) and a progestin hormone (norethindrone). It works by preventing symptoms, such as feelings of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating (hot flashes) in women during menopause.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Your doctor will tell you how much medicine to use. Do not use more than directed.
This medicine comes in a dispenser pack with a calendar reminder dial.To use this dispenser, first turn the inner disc so the current day of the week is lined up with the plastic tab. Pull the plastic tab up and break if off. Remove the first tablet. To get the next tablet out (on the next day), turn the dial one space clockwise as shown by the arrow. The dial can be turned only after the tablet in the opening has been removed. This will help you remember to take 1 tablet every day.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some medicines can affect how estradiol/norethindrone works. Tell your doctor if you are using St John’s wort, carbamazepine, clarithromycin, erythromycin, itraconazole, ketoconazole, phenobarbital, rifampin, or ritonavir.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to estradiol or norethindrone, you are pregnant, or you have liver disease. Do not use it if you have had breast cancer, uterine cancer, unusual vaginal bleeding, or problems with blood clots (such as deep vein thrombosis or stroke).
Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.
Tell your doctor if you have kidney disease, heart disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, porphyria, lupus, an underactive thyroid, high blood pressure, or high cholesterol. Tell your doctor if you have ever had liver problems caused by pregnancy or estrogen, if you smoke, or if you had a hysterectomy.
This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clots Higher risk of endometrial cancer, breast cancer, or uterine cancer Higher risk of dementia Gallbladder disease High calcium levels
You may need to stop using this medicine for a few weeks before and after surgery, or if you need to stay in bed for a long time. This is because of the risk of blood clots.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. You should have regular pelvic exams, breast exams, and mammograms as directed by your doctor.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Numbness or weakness on one side of your body
Unusual or unexpected vaginal bleeding or heavy bleeding
If you notice these less serious side effects, talk with your doctor:
Light, irregular vaginal bleeding or spotting
Mild headache or trouble sleeping
Nausea, stomach pain, or upset stomach
Swelling in your hands, ankles, or feet
Swollen or tender breasts
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Activella, Lopreeza, Mimvey, Mimvey Lo
There may be other brand names for this medicine.