Everolimus (By mouth)
Antineoplastic Agent, Immune Suppressant (About this – PubMed Health)
Uses of This Medicine
Everolimus is used to treat advanced (late-stage) kidney cancer in patients who have already received other medicines that did not work well. It is also used to treat subependymal giant cell astrocytoma (SEGA; a brain tumor), renal angiomyolipoma (a non-cancerous kidney tumor), and advanced (late-stage) pancreatic neuroendocrine tumors (PNET; a pancreas tumor that spreads to the nervous system) that will not be treated with surgery. Everolimus is used together with exemestane to treat advanced (late-stage) hormone receptor-positive, HER-2 negative breast cancer in postmenopausal women who have already received other medicines that did not work well.
Everolimus works by interfering with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal body cells may also be affected, other unwanted effects will also occur. It belongs to the group of medicines known as antineoplastics (cancer medicines).
Everolimus is also used together with other medicines to lower the body’s natural immunity in patients who receive kidney or liver transplants. When a patient receives an organ transplant, the body’s white blood cells try to get rid of (reject) the transplanted organ. Everolimus works to suppress the immune system and prevents the white blood cells from getting rid of the transplanted organ.
Before you begin treatment with everolimus, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.
This medicine is available only with your doctor’s prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, everolimus is used in certain patients with the following medical conditions:
Waldenstrom’s macroglobulinemia (rare type of slow growing non-Hodgkin lymphoma).
Other uses (PubMed Health)
How To Use
Tablet, Tablet for Suspension
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Take this medicine the same way every day. This means take it at the same time, and always take it with food or always without food.
Regular tablet: Swallow whole with a glass of water. Do not crush, break, or chew it.
Tablet for suspension: Dissolve the tablet in water before you take it. Do not swallow it. Once dissolved, the mixture must be used within 60 minutes. If it is not, throw that dose away and prepare another. If you are preparing the oral suspension for another person, wear disposable gloves. There are 2 ways to prepare the suspension:Small cup: Put the tablet in a cup with 25 milliliters (mL) water. Do not break or crush the tablet. Wait 3 minutes, and then gently stir the mixture. Drink the mixture right away. Refill the glass with the same amount of water and drink it right away so you get all the medicine. Oral syringe: Follow the directions that came with your medicine. Dissolve the tablet inside a 10 mL syringe, using 5 mL water and 4 mL of air. The tablet will take 3 minutes to dissolve. Slowly turn the syringe upside down 5 times. Place the syringe in the mouth and slowly give the dose. Fill the syringe with water and air again, and give this to the patient to make sure all of the medicine is taken. Use a new syringe for each dose.
Do not use the regular tablet and the tablet for suspension together. Use only 1 form of this medicine.
Kidney or liver transplant patients: You may have to take this medicine for the rest of your life to prevent rejection of the organ. Do not change your dose or stop taking this medicine without talking to your doctor. Take all medicines that are part of your treatment as prescribed, especially ones that you need to take at the same time as everolimus.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose:Zortress®: Take the dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Afinitor® or Afinitor® Disperz: If it is less than 6 hours from the time you normally take the dose, you may still take it. If it is more than 6 hours, skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep your medicine in the original package until you are ready to use it.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some foods and medicines can affect how everolimus works. Tell your doctor if you are using any of the following:Amprenavir, aprepitant, atazanavir, carbamazepine, clarithromycin, cyclosporine, digoxin, diltiazem, erythromycin, fluconazole, fosamprenavir, indinavir, itraconazole, ketoconazole, midazolam, nefazodone, nelfinavir, octreotide, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, St John’s wort, telithromycin, verapamil, or voriconazole. An ACE inhibitor blood pressure medicine Steroid medicine (such as dexamethasone, prednisolone, prednisone)
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to everolimus or similar medicines, or if you are pregnant.
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control during treatment and for at least 8 weeks after you stop treatment.
This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
Tell your doctor if you are breastfeeding, or if you have kidney problems, liver problems, any type of infection (such as hepatitis B), diabetes, high cholesterol, or a history of skin cancer or lymphoma. Tell your doctor if you are lactose intolerant or have Lapp lactase deficiency or glucose–galactose malabsorption.
This medicine may cause the following problems:Noninfectious pneumonitis Slow wound healing Kidney failure Increased risk of skin cancer and lymphoma Angioedema (when used with an ACE inhibitor blood pressure medicine) Increased risk of blood clots in the new kidney or liver (transplant patients)
This medicine may weaken your immune system and increase your risk for infections. Tell your doctor right away if you notice any changes in your health.
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Because this medicine increases your risk for skin cancer, wear sunscreen when you are outside. Do not use sunlamps or tanning beds. Tell your doctor if you notice any growths or changes on your skin.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Decrease in how much or how often you urinate, painful urination, cloudy or bloody urine
Unusual bleeding, bruising, or weakness
Yellow skin or eyes
If you notice these less serious side effects, talk with your doctor:
Change in sense of taste
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Afinitor, Afinitor Disperz, Zortress
There may be other brand names for this medicine.