Promethazine (Into the rectum)
Antiemetic, Antivertigo, Gastrointestinal Agent (About this – PubMed Health)
Uses of This Medicine
Promethazine is used to relieve or prevent the symptoms of hay fever, allergic conjunctivitis (inflammation of the eye), and other types of allergy or allergic reactions. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult .
Promethazine is also used to prevent and control motion sickness, nausea, vomiting, and dizziness. In addition, it may be used to help people go to sleep and control their pain or anxiety before or after surgery or other procedures .
Promethazine may also be used for other conditions as determined by your doctor .
This medicine is only available with your doctor’s prescription .
Other uses (PubMed Health)
How To Use
Your doctor will tell you how much medicine to use. Do not use more than directed.
Keep lying down for about 15 minutes to keep the suppository from coming out before it melts. Then, wash your hands again.
To make the suppository easier to insert, you may use a lubricating gel such as K-Y® Jelly, but do not use petroleum jelly (Vaseline®).
Never take rectal suppositories by mouth.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
You may store the suppositories in the refrigerator, but do not freeze them.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some medicines can affect how promethazine works. Tell your doctor if you are also using an MAO inhibitor (MAOI).
Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to promethazine or another phenothiazine medicine, or while you are having asthma symptoms or similar breathing problems.
Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, heart or blood vessel disease, glaucoma, a stomach ulcer, bowel problems, an enlarged prostate, bone marrow problems, trouble urinating, or seizures. Also tell your doctor if you have breathing problems, such as COPD, asthma, or sleep apnea.
This medicine may cause the following problems:Breathing problems, which could be life-threatening Neuroleptic malignant syndrome (a nerve disorder that can be life-threatening) Liver problems
Use in children: Give the medicine exactly as directed by the child’s doctor. Too much of this medicine can cause death in a young child. Do not give this medicine to a child younger than 2 years old, unless your doctor tells you to.
This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Fever, sweating, confusion, uneven heartbeat, muscle stiffness
Lightheadedness or fainting
Seeing or hearing things that are not there (especially in children)
Trouble breathing, slow breathing
Twitching or muscle movements you cannot control
Yellow skin or eyes
If you notice these less serious side effects, talk with your doctor:
Nausea, vomiting, constipation
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Phenadoz, Phenergan, Promethegan
There may be other brand names for this medicine.