Mesalamine (By mouth)
Anti-Inflammatory, Gastrointestinal Agent (About this – PubMed Health)
Uses of This Medicine
This medicine is available only with your doctor’s prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, mesalamine is used in certain patients with the following medical conditions:
Other uses (PubMed Health)
How To Use
Delayed Release Capsule, Long Acting Capsule, Tablet, Delayed Release Tablet, Coated Tablet
Your doctor will tell you how much medicine to use. Do not use more than directed.
Swallow the capsule or tablet whole. Do not open, break, crush, or chew it.
Delayed-release capsule: Take at least 1 hour before or 2 hours after a meal.
Lialda® delayed-release tablet: Take with food.
Pentasa® extended-release capsule: You may swallow the capsule whole, or open the capsule and sprinkle the contents on applesauce or yogurt. Swallow the mixture right away without chewing.
Part of the medicine may pass into your stools. Tell your doctor if this happens repeatedly.
Keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. The medicine bottle might come with a small pouch (desiccant) inside it. Keep this pouch in the bottle to protect the medicine from moisture.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some medicines can affect how mesalamine works. Tell your doctor if you are also using any of the following:Azathioprine Mercaptopurine Antacids NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to mesalamine or an aminosalicylate or salicylate medicine (such as aspirin).
Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease including a history of myocarditis or pericarditis, or a history of stomach problems (such as blockage, pyloric stenosis). Tell your doctor if you had an allergic reaction to sulfasalazine.
This medicine may cause the following problems:Mesalamine-induced acute intolerance syndrome Kidney problems Heart problems (myocarditis, pericarditis) Liver failure in people who already have liver disease
Tell your doctor if you have phenylketonuria (PKU). The Apriso™ extended-release capsules contain aspartame, which may be a problem for people who have PKU.
Carefully follow all directions if you are changing from one brand of this medicine to another brand. Different brands may have different instructions.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Chest pain, trouble breathing
Decrease in how much or how often you urinate, difficult or painful urination
Fast, slow, or pounding heartbeat
If you notice these less serious side effects, talk with your doctor:
Mild constipation, diarrhea, gas, nausea, vomiting, or stomach upset
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Apriso, Asacol 800, Asacol HD, Delzicol, Lialda, Pentasa
There may be other brand names for this medicine.