Amlodipine/Valsartan/Hydrochlorothiazide (By mouth)
am-LOE-di-peen BES-i-late, val-SAR-tan, hye-droe-klor-oh-THYE-a-zide
Antihypertensive (About this – PubMed Health)
Uses of This Medicine
Amlodipine, valsartan, and hydrochlorothiazide is a combination of medicines that is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a heart failure or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.
Amlodipine is a calcium channel blocker (CCB). It affects the movement of calcium into the cells of the heart and blood vessels. As a result, amlodipine relaxes the blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.
Valsartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes the blood vessels to tighten. As a result, valsartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Do not use this medicine together with aliskiren.
Some medicines can affect how this medicine works. Tell your doctor if you are using any of the following:Atropine, biperiden, carbamazepine, clarithromycin, cyclophosphamide, cyclosporine, digoxin, heparin, itraconazole, ketoconazole, lithium, methotrexate, rifampin, ritonavir, simvastatin, sildenafil, tacrolimus, telithromycin Diuretic (water pill) Insulin or diabetes medicine that you take by mouth NSAID pain or arthritis medicine (including aspirin, diclofenac, ibuprofen, naproxen) Steroids (including hydrocortisone, methylprednisolone, prednisone, prednisolone, dexamethasone)
Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
Alcohol, narcotic pain medicine, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to amlodipine, valsartan, hydrochlorothiazide, or sulfa drugs, or if you are pregnant.
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
Tell your doctor if you are breastfeeding, or if you have kidney problems, liver disease, diabetes, gout, heart or blood vessel disease, heart failure, angina, high cholesterol, lupus, trouble urinating, or a history of allergies, asthma, or heart attack.
This medicine may cause the following problems:Worsening angina or risk of heart attack in people with heart problems Kidney problems Low potassium levels Vision problems
This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel dizzy or lightheaded.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Change in how much or how often you urinate, bloody or cloudy urine
Chest pain that may spread, trouble breathing, unusual sweating
Confusion, weakness, numbness in your hands, feet, or lips
Eye pain, vision changes, seeing halos around lights
Fast, slow, or uneven heartbeat
Lightheadedness, dizziness, fainting
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.