Urokinase (By injection)
Thrombolytic (About this – PubMed Health)
Uses of This Medicine
This medicine was available only with your doctor’s prescription.
This medicine is not available in the United States as of October 2010.
Other uses (PubMed Health)
How To Use
Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
A nurse or other health provider will give you this medicine.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Make sure your doctor knows if you are also using a blood thinner (such as warfarin, Coumadin®) or a pain or arthritis medicine (such as aspirin, diclofenac, etodolac, ibuprofen, indomethacin, Advil®, Aleve®, Celebrex®, Daypro®, Dolobid®, Feldene®, Indocin®, Motrin®, Orudis®, Relafen®, or Voltaren®).
If you have a fever after receiving urokinase, do not use aspirin or ibuprofen (Advil®, Motrin®) to treat the fever unless your doctor tells you to.
When Not To Use
You should not receive this medicine if you have had an allergic reaction to urokinase, or if you have internal bleeding, a bleeding disorder, or high blood pressure that is not well-controlled. You should not receive this medicine if you have had a brain tumor or a recent stroke. You should not receive this medicine if you have had recent head or spinal surgery, or had any emergency that required CPR.
Tell your doctor if you have recently had a baby, had major surgery, had a biopsy of one of your organs (such as your liver or kidney), or had gastric (stomach) bleeding such as a bleeding ulcer, colitis, or bleeding from your rectum.
This medicine is made from donated human kidney cells. Some human blood or tissue products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made of human blood or tissue has been greatly reduced in recent years. Although the risk is low, talk with your doctor if you have concerns.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Bleeding from any part of your body, especially an incision, or where your IV needle is placed.
Blood in your urine or stools.
Decrease in how much or how often you urinate.
Fever, chills, or shaking.
Muscle aches, pain, tenderness, or stiffness.
Unusual bruising or discoloration of your fingers or toes.
If you notice these less serious side effects, talk with your doctor:
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.