Drospirenone/Estradiol (By mouth)
Treats symptoms of menopause.
Uses of This Medicine
Drospirenone and estradiol combination is used to treat moderate to severe hot flashes and other symptoms of menopause or low amounts of estrogen in women who still have a uterus (womb). It is also used to treat changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by menopause in women who still have a uterus.
Drospirenone and estradiol are female hormones called progestins and estrogens that make up this combination medicine. This medicine works by preventing symptoms, such as feeling of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating (hot flashes) in women during menopause. .
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Your doctor will tell you how much medicine to use. Do not use more than directed.
Swallow the tablet whole with liquids. Do not break, crush, or chew it.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. You may have vaginal bleeding if you forget to take your medicine for several days.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some foods and medicines can affect how this medicine works. Tell your doctor if you are using any of the following:St John’s wort, carbamazepine, clarithromycin, erythromycin, heparin, itraconazole, ketoconazole, phenobarbital, rifampin, ritonavir Medicine to lower blood pressure, an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen), a diuretic (water pill), or a potassium supplement
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to drospirenone or estradiol. Do not use it if you may be pregnant, or if you have adrenal gland disease, kidney disease, liver disease, or unusual vaginal bleeding that has not been checked by a doctor. Do not use this medicine if you have a history of breast or uterine cancer, heart attack, stroke, or blood clots.
Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.
Tell your doctor if you have endometriosis, asthma, diabetes, epilepsy, hereditary angioedema, lupus, migraines, porphyria, a thyroid problem, heart disease, high blood pressure, or high cholesterol. Tell your doctor if you had liver problems caused by pregnancy or estrogen.
Do not breastfeed while you are using this medicine, unless your doctor says it is okay.
This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clots Higher risk of endometrial, breast, or uterine cancer Higher risk of dementia Gallbladder disease High blood pressure
Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine before you have surgery or if you need to stay in bed for a long time. This medicine may affect the results of certain medical tests.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Chest pain, trouble breathing, coughing up blood
Confusion, weakness, uneven heartbeat, numbness in your hands, feet, or lips
Unusual vaginal bleeding or discharge
Vision blurring or loss
If you notice these less serious side effects, talk with your doctor:
Breast pain, swelling, or tenderness
Mild stomach pain
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.