Hydralazine/Hydrochlorothiazide (By mouth)
hye-DRAL-a-zeen hye-droe-KLOR-ide, hye-droe-klor-oh-THYE-a-zide
Vasodilator/Thiazide Combination (About this – PubMed Health)
Uses of This Medicine
High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure also may increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Hydralazine works by relaxing blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. The hydrochlorothiazide is a type of medicine known as a thiazide diuretic and helps reduce the amount of water in the body by acting on the kidneys to increase the flow of urine.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Take this medicine exactly as your doctor ordered. Even if you feel fine your blood pressure can still be high.
It is best to take this medicine on an empty stomach.
Carefully follow your doctor’s instructions about any special diet. You may need to eat foods that are high in potassium (such as oranges or bananas) to prevent potassium loss while you are using this medicine.
If a dose is missed:
Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Make sure your doctor knows if you are using diazoxide (Proglycem®), lithium (Eskalith®), methyldopa (Aldomet®), or MAO inhibitors (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate®. Tell your doctor if you use digoxin (Lanoxin®), or steroids such as dexamethasone, prednisolone, prednisone, or Medrol®. Make sure your doctor knows if you also use corticotropins (ACTH, H.P. ACTHAR®). Tell your doctor if you use pain or arthritis medicine such as aspirin, ibuprofen, naproxen, Advil®, Aleve®, Bextra®, Celebrex®, Ecotrin®, or Motrin®. These medicines may also be called “NSAID’s”.
Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Make sure your doctor knows if you drink alcohol on a regular basis.
Ask your doctor before you use low-salt milk, potassium supplements, or salt substitutes that contain potassium.
When Not To Use
You should not use this medicine if you have had an allergic reaction to hydralazine, hydrochlorothiazide, or sulfa drugs. You should not use this medicine if you have coronary artery disease, rheumatic heart disease, or if you are unable to urinate.
Make sure your doctor knows if you are pregnant or breast feeding, or if you have kidney or liver disease, gout, diabetes, lupus, or if you are on dialysis. Tell your doctor if you have a history of heart or parathyroid disease, pancreatitis, asthma, or if you have had a stroke or any surgeries.
This medicine may make you dizzy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
If you stop using this medicine, your blood pressure may go up. High blood pressure usually has no symptoms. Even if you feel well, do not stop using the medicine without asking your doctor.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Chest pain, fast or uneven heartbeat.
Decrease in how much or how often you urinate.
Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
Swelling in your hands, ankles, or feet.
Unusual bleeding, bruising, or weakness.
Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
Appetite loss, mild nausea or vomiting.
Diarrhea or constipation.
Headache, or light-headedness.
Stuffy nose or watery eyes.
Warmth or redness in your face, neck, arms, or upper chest.
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.