Azilsartan/Chlorthalidone (By mouth)
ay-zil-SAR-tan me-DOX-oh-mil, klor-THAL-i-done
Antihypertensive (About this – PubMed Health)
Uses of This Medicine
Azilsartan and chlorthalidone combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.
Azilsartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to tighten. As a result, azilsartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some medicines and foods can affect how azilsartan/chlorthalidone works. Tell your doctor if you are taking any of the following:A diuretic (water pill), such as furosemide, hydrochlorothiazide, torsemide An NSAID pain or arthritis medicine, such as aspirin, diclofenac, ibuprofen, naproxen Digoxin Lithium
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to azilsartan or to chlorthalidone, or if you are pregnant or not able to urinate.
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. This is more likely to happen when you begin to use the medicine or if you become dehydrated. Stand or sit up slowly if you are dizzy. Drink more liquids if you exercise, sweat more than usual, or have diarrhea or are vomiting.
This medicine may cause the following problems:Low potassium levels Worsening kidney problems Worsening symptoms of gout
Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Change in how much or how often you urinate
Confusion, weakness in your hands and feet, uneven heartbeat, trouble breathing
Joint pain or swelling
Lightheadedness, dizziness, fainting
Unusual tiredness or weakness
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.