Mesalamine (Into the rectum)
Treats ulcerative proctitis.
Anti-Inflammatory, Gastrointestinal Agent (About this – PubMed Health)
Uses of This Medicine
Mesalamine is used to treat an inflammatory bowel disease, such as ulcerative colitis. Mesalamine suppositories are used to treat mild to moderate active ulcerative proctitis (inflammation of the rectum). It works inside the intestines (bowels) to reduce the inflammation and other symptoms of the disease.
This medicine is available only with your doctor’s prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, mesalamine is used in certain patients with the following medical condition:
Ulcerative colitis, history of—prevent it from occurring again.
Other uses (PubMed Health)
How To Use
Your doctor will tell you how much medicine to use. Do not use more than directed.hands with soap and water before and after using this medicine. Lie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Insert the applicator tip into your rectum about an inch. Gently squeeze the bottom of the bottle to release the enema. Remove the bottle and throw it away. You may need to hold the liquid in your rectum for several minutes or hours. This may be difficult or feel uncomfortable. It should become easier to do as you continue to use the medicine.
Suppository:Never take rectal suppositories by mouth. Use this medicine at bedtime, unless your doctor tells you otherwise. Before you insert a suppository, go to the bathroom and empty your bladder and, if possible, have a bowel movement. This medicine will stain any surface it touches (such as clothing, bedsheets, floors, and countertops). To protect your clothing, consider wearing a sanitary napkin or adult undergarment such as Depend®. Protect your sheets by placing a waterproof pad on your bed. Wash your hands with soap and water before and after using this medicine. Remove the foil or wrapper from the suppository before inserting it. Do not keep the suppository in your hand too long or it will begin to melt. To make the suppository easier to insert, you may use a lubricating gel such as K-Y® Jelly, but do not use petroleum jelly (Vaseline®). Lie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Gently push the pointed end of the suppository into the rectum about 1 inch. The medicine needs to remain in your body for 1 to 3 hours or longer. Try not to use the bathroom for at least that length of time after inserting the suppository.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
You may store the suppositories in the refrigerator, but do not freeze them. Store the enema at room temperature. Keep it away from heat, moisture, or direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some medicines can affect how mesalamine works. Tell your doctor if you are also taking mesalamine by mouth, azathioprine, mercaptopurine, or an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen).
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to mesalamine or salicylates (such as aspirin). Do not use the rectal suppository if you are allergic to saturated vegetable fat, such as shortening.
Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or a history of heart disease (such as myocarditis or pericarditis). Tell your doctor if you have had an allergic reaction to sulfasalazine.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Change in how much or how often you urinate
Chest pain, trouble breathing
Fast, slow, or pounding heartbeat
If you notice these less serious side effects, talk with your doctor:
Mild headache or dizziness
Mild stomach discomfort, nausea, diarrhea, gas
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Canasa, Mesasal, Pentasa, Rowasa, Salofalk, sfRowasa
There may be other brand names for this medicine.