Oxycodone/Ibuprofen (By mouth)
eye-bue-PROE-fen, ox-i-KOE-done hye-droe-KLOR-ide
Treats moderate to severe pain. This medicine contains a narcotic pain reliever and an NSAID.
Drug classes
Opioid/NSAID Combination (About this – PubMed Health)
Uses
Uses of This Medicine
Ibuprofen and oxycodone combination is used to relieve acute, moderate to severe pain.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in this combination to relieve inflammation, swelling, and pain.
Oxycodone is a narcotic analgesic that acts in the central nervous system to relieve pain. If oxycodone is used for a long time, it may become habit-forming (causing mental or physical dependence). Physical dependence may lead to withdrawal side effects when you stop taking the medicine. Since ibuprofen and oxycodone combination is only used for short-term (7 days or less) relief of pain, physical dependence probably will not occur.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Tablet
Your doctor will tell you how much medicine to use. Do not use more than directed.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Drink plenty of liquids to help avoid constipation.
Missed dose:Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some medicines and food can affect how oxycodone and ibuprofen work. Tell your doctor if you are also using any of the following:
Another NSAID, including aspirin Antidepressant Diuretic, including furosemide or a thiazide ACE inhibitor Corticosteroid, including hydrocortisone, methylprednisolone, prednisone, prednisolone, dexamethasone) Blood thinner, including warfarin Lithium or methotrexate Monoamine oxidase inhibitor (MAOI)Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
Do not drink alcohol while you are using this medicine. Do not take any medicine that contains alcohol.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction (including asthma) to ibuprofen, oxycodone, aspirin, or similar pain medicines.
Warnings
Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of your pregnancy.
Tell your doctor if have kidney disease, liver disease, bleeding problems, high blood pressure or circulation problem, asthma or other lung disease, or heart failure or other heart problems. Tell your doctor if you have lupus, Addison disease or other thyroid problems, trouble urinating, prostate disorder, or a history of head injury, brain tumor, seizure, or pancreatitis or digestive problems.
This medicine might cause the following problems:
Anemia or bleeding problems Bleeding and ulcers in your stomach or intestines High blood pressure Higher risk of heart attack or stroke Kidney damage Liver damageThis medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Too much of this medicine can cause death. Symptoms of an overdose include extreme slow heartbeat, seizure, and cold, clammy skin.
This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
Keep all medicine out of the reach of children. Never share your medicine with anyone. An overdose in a child could cause death.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blistering, peeling, or red skin rash
Change in how much or how often you urinate
Chest pain that may spread, trouble breathing, nausea, unusual sweating, fainting
Chest pain, trouble breathing, or coughing up blood
Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
Extreme weakness, shallow breathing, slow heartbeat, sweating, cold or clammy skin
Fever, neck pain or stiff neck
Lightheadedness, dizziness, fainting
Numbness or weakness in one side of your body, sudden or severe headache, problems with vision, speech, or walking
Rapid weight gain, swelling in your hands, ankles, or feet
Severe stomach pain, vomiting blood, bloody or black, tarry stools
Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
Constipation, diarrhea, heartburn, nausea
Sleepiness
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Combunox
There may be other brand names for this medicine.