Avanafil (By mouth)
Treats erectile dysfunction (trouble having an erection).
Erectile Dysfunction Agent (About this – PubMed Health)
Uses of This Medicine
Avanafil is used to treat men who have erectile dysfunction (also called sexual impotence). Avanafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works.
Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body’s normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, avanafil helps to maintain an erection after the penis is stroked by increasing blood flow to the penis. Without physical action to the penis, such as that occurring during sexual intercourse, avanafil will not work to cause an erection.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Take this medicine about 15 minutes before you have sex. Do not take it more than once a day. Always allow at least 24 hours between doses.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Do not use this medicine if you also use a nitrate medicine, often used to treat angina or high blood pressure. Nitrate medicines include nitroglycerin, isosorbide, amyl nitrate, butyl nitrate, and nitrite. Do not use this medicine if you also use riociguat.
Some foods and medicines can affect how avanafil works. Tell your doctor if you are using any of the following:Amprenavir, aprepitant, atazanavir, clarithromycin, desipramine, erythromycin, fluconazole, fosamprenavir, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, omeprazole, ritonavir, rosiglitazone, saquinavir, telithromycin Medicine to treat high blood pressure or prostate problems (including alfuzosin, amlodipine, diltiazem, doxazosin, enalapril, prazosin, silodosin, tamsulosin, terazosin, verapamil)
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to avanafil.
Tell your doctor if you have kidney disease, liver disease, bleeding problems, diabetes, heart or blood vessel disease, high blood pressure, high cholesterol, vision or eye problems, a stomach ulcer, or a penis with an abnormal shape. Tell your doctor if you have sickle cell anemia, leukemia, or multiple myeloma.
Tell your doctor if you use any other medicine that might cause low blood pressure, because avanafil might also lower your blood pressure. If your blood pressure gets too low, you might faint or have other health problems.
Tell your doctor if you drink alcohol. You are more likely to have a drop in blood pressure if you have more than 3 drinks of alcohol at a time while you are taking this medicine.
This medicine may cause your penis to become erect when you do not want an erection or to stay erect for longer than you want.
This medicine will not protect you from sexually transmitted infections (including HIV or AIDS).
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Erection that is painful or lasts longer than 4 hours
Fast, pounding, or uneven heartbeat
Lightheadedness or fainting
Sudden loss of vision in one or both eyes
If you notice these less serious side effects, talk with your doctor:
Stuffy or runny nose
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.