Rosiglitazone/Metformin (By mouth)
met-FOR-min hye-droe-KLOR-ide, roe-zi-GLI-ta-zone MAL-ee-ate
Treats type 2 diabetes.
Hypoglycemic (About this – PubMed Health)
Uses of This Medicine
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
It is best to take this medicine with food or milk.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some foods and medicines can affect how rosiglitazone/metformin works. Tell your doctor if you are using the following:Amiloride, digoxin, gemfibrozil, insulin, isoniazid, morphine, nicotinic acid, phenytoin, procainamide, quinidine, quinine, ranitidine, rifampin, triamterene, trimethoprim, or vancomycin Asthma medicine, blood pressure medicine, decongestants, a diuretic (water pill), a phenothiazine medicine (such as chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisone, prednisolone, dexamethasone), thyroid medicine, or birth control pills
Do not drink a lot of alcohol while you are using this medicine. Heavy alcohol use can increase your risk for lactic acidosis.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to rosiglitazone or metformin, or if you have severe heart failure, severe kidney disease, or metabolic acidosis.
Tell your doctor if you are pregnant or breastfeeding, or if you have heart failure, heart problems, or you had a heart attack. Tell your doctor if you have kidney disease, liver disease, edema (fluid retention or swelling), macular edema, an adrenal or pituitary gland problem, or a vitamin B12 deficiency.
This medicine may cause the following problems:Lactic acidosis (a buildup of acid in the blood that can be life-threatening, but occurs rarely) An increased risk of heart or blood vessel problems Liver problems Macular edema (swelling in the back of the eye) An increased risk for bone fracture Low blood sugar
Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using it before you have surgery, an X-ray, a CT scan, or other medical tests.
Even if you had problems ovulating and had irregular periods in the past, this medicine may cause you to ovulate. If you could become pregnant, you should discuss birth control options with your doctor.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Blurred vision or other changes in vision
Extreme weakness, tiredness, confusion, rapid breathing, trouble breathing, and muscle pain
Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
If you notice these less serious side effects, talk with your doctor:
Mild nausea or vomiting, diarrhea, or upset stomach
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.