Regorafenib (By mouth)
Antineoplastic Agent (About this – PubMed Health)
Uses of This Medicine
Regorafenib is used to treat metastatic cancer (cancer that has spread) of the colon and rectum. It is used in patients who have already been treated with other cancer medicines that did not work well. Regorafenib prevents the growth of tumors.
Regorafenib is also used to treat metastatic gastrointestinal stromal tumors (GIST) in patients who have already received other medicines that did not work well. GIST is a rare cancer that affects the stomach, bowel, or esophagus.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Your doctor will tell you how much medicine to use. Do not use more than directed.
Take the tablet at the same time each day with a low-fat meal (less than 30% fat) that is less than 600 calories.
Swallow the tablet whole with water. Do not crush, break, or chew it.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the tablets at room temperature, in the original container. Do not place the tablets in daily or weekly pill boxes. Keep the medicine away from heat, moisture, and direct light. Throw away any unused medicine 7 weeks after you first open the bottle.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some foods and medicines can affect how regorafenib works. Tell your doctor if you are using any of the following:Carbamazepine, clarithromycin, itraconazole, ketoconazole, nefazodone, phenobarbital, phenytoin, posaconazole, rifampin, telithromycin, voriconazole, St John’s wort Blood thinner (including warfarin)
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to regorafenib, or if you are pregnant.
This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment and for at least 2 months after treatment ends.
This medicine may cause the following problems:Liver problems Increased risk of bleeding Serious skin reactions Increased risk of heart attack, high blood pressure Reversible posterior leukoencephalopathy syndrome (brain disorder) Gastrointestinal perforation (tear in your stomach or bowels)
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may cause slow wound healing. You may need to stop taking it before you have surgery.
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Chest pain that may spread, trouble breathing, unusual sweating, fainting
Red or dark brown urine, bloody or black stools, unexplained nosebleeds, vomit that looks like coffee grounds
Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
Swelling or pain in your mouth, voice changes
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.