Rifampin/Isoniazid/Pyrazinamide (By mouth)
rif-AM-pin, eye-soe-NYE-a-zid, pir-a-ZIN-a-mide
Treats tuberculosis (TB).
Antitubercular Combination (About this – PubMed Health)
Uses of This Medicine
Rifampin, isoniazid, and pyrazinamide is a combination anti-infective medicine. This combination medicine is used to treat tuberculosis (TB). It may be taken alone or with one or more of other medicines for TB.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Your doctor will tell you how much medicine to use. Do not use more than directed.
Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
Your doctor may also want you to take pyridoxine vitamin B6) every day to help prevent or lessen some of the side effects of isoniazid.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
There are many other drugs that interact with this medicine. Make sure your doctor knows all other medicines you are using. Some of the drugs of concern are phenytoin, digoxin, and blood thinners such as warfarin.
If you use an antacid, take it at least 1 hour after you take rifampin/isoniazid/pyrazinamide.
Birth control that uses hormones, such as birth control pills, may not work while you are using this medicine. Use a different kind of birth control, if needed.
Avoid foods and drinks that are high in tyramine, because your blood pressure could get dangerously high. Your doctor should give you a complete list. In general, do not eat anything aged or fermented, such as most cheese, most alcohol, cured meat (such as salami), sauerkraut, and soy sauce. Check the expiration dates on packages. Tyramine levels get higher as food gets older or if it has not been refrigerated properly.
When Not To Use
This medicine may cause the following problems:Liver damage High levels of uric acid, which causes symptoms of gout
Tell your doctor if you drink alcohol. You could have a higher risk of liver problems.
Call your doctor if your symptoms do not improve or if they get worse.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Blurred vision, vision changes, trouble seeing
Joint pain or swelling
Numbness, tingling, or burning pain in your hands, arms, legs, or feet
If you notice these less serious side effects, talk with your doctor:
Mild nausea, vomiting, diarrhea, or stomach pain
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.