Ezetimibe/Simvastatin (By mouth)
Antihyperlipidemic (About this – PubMed Health)
Uses of This Medicine
Ezetimibe and simvastatin combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels.
Ezetimibe is a cholesterol absorption inhibitor and simvastatin is an HMG-CoA reductase inhibitor, or statin. This medicine will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Take the medicine in the evening, unless your doctor tells you otherwise.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Do not use this medicine together with boceprevir, clarithromycin, cobicistat-containing medicines, cyclosporine, danazol, erythromycin, gemfibrozil, itraconazole, ketoconazole, nefazodone, posaconazole, telaprevir, telithromycin, voriconazole, or certain medicines to treat HIV/AIDS.
Some medicines can affect how this medicine works. Tell your doctor if you are using amiodarone, cholestyramine, colchicine, digoxin, dronedarone, fenofibrate, fenofibric acid, lomitapide, niacin (vitamin B3), ranolazine, a blood thinner (such as warfarin), or blood pressure medicine (such as amlodipine, diltiazem, verapamil).
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
When Not To Use
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
This medicine may cause the following problems:Liver problems Myopathy or rhabdomyolysis (muscle damage)
Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Muscle pain, tenderness, or weakness
If you notice these less serious side effects, talk with your doctor:
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.