Micromedex Detailed Drug Information for the Consumer [Internet]. Truven Health Analytics; 1974-2016.
Liotrix (Oral route)
lee-voe-thye-ROX-een SOE-dee-um, lye-oh-THYE-roe-neen SOE-dee-umBrand Name(s)
In the US: Euthroid, Thyrolar
Dosage forms
Tablet
Classifications
Therapeutic: Thyroid Supplement
Uses of This Medicine
Liotrix is used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. It is also used to help decrease the size of enlarged thyroid glands (known as goiter) and to treat thyroid cancer .
Liotrix is also used in some medical tests to help diagnose problems with the thyroid gland .
This medicine is available only with your doctor’s prescription .
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Pregnancy
Pregnancy Category Explanation All Trimesters A Adequate studies in pregnant women have not shown an increased risk of fetal abnormalities.Breast Feeding
Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
AmifampridineUsing this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Amineptine Amitriptyline Amitriptylinoxide Amoxapine Clomipramine Dasabuvir Desipramine Dibenzepin Doxepin Imipramine Ketamine Lofepramine Maprotiline Melitracen Mirtazapine Nortriptyline Opipramol Protriptyline Tianeptine TrimipramineUsing this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Acenocoumarol Aluminum Carbonate, Basic Aluminum Hydroxide Aluminum Phosphate Anisindione Calcium Acetate Calcium Carbonate Calcium Citrate Cholestyramine Chromium Ciprofloxacin Colesevelam Conjugated Estrogens Dexlansoprazole Dicumarol Dihydroxyaluminum Aminoacetate Dihydroxyaluminum Sodium Carbonate Eltrombopag Esomeprazole Esterified Estrogens Estradiol Estriol Estrone Estropipate Fosphenytoin Imatinib Iron Kelp Lansoprazole Lanthanum Carbonate Lopinavir Magaldrate Magnesium Carbonate Magnesium Hydroxide Magnesium Oxide Magnesium Trisilicate Omeprazole Pantoprazole Phenindione Phenprocoumon Phenytoin Rabeprazole Rifampin Rifapentine Ritonavir Sevelamer Simvastatin Soybean WarfarinOther Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Enteral NutritionOther Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Adrenal insufficiency (untreated) or Thyrotoxicosis (untreated, overactive thyroid)—This medicine should NOT be used in patients with any of these conditions . Clotting disorder or Diabetes or Heart disease (history of) or Other adrenal gland problems—Use with caution. Dosage adjustment may be needed .Proper Use of This Medicine
This medicine usually needs to be taken for the rest of your life. Do not stop taking this medicine or change your doses without first checking with your doctor. It may take several weeks before you start to notice an improvement in your symptoms .
Dosing
The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (tablet): For the treatment of hypothyroidism: Adults—At first, one tablet of liotrix (Thyrolar-1/2) containing 6.25 microgram (mcg) of liothyronine and 25 mcg of levothyroxine once a day. Your doctor may increase your dose by one tablet of liotrix (Thyrolar-1/4) containing 3.1 mcg of liothyronine and 12.5 mcg of levothyroxine every 2 to 3 weeks. However, the dose is usually not more than one tablet of liotrix (Thyrolar-3) containing 37.5 mcg of liothyronine and 150 mcg of levothyroxine once a day. Children—Follow dosing for the treatment of congenital hypothyroidism . For the treatment of congenital hypothyroidism: Children 0 to 6 months of age—At first, 3.1 mcg of liothyronine and 12.5 mcg of levothyroxine once a day. Doses may be increased as needed. However, the dose is usually not more than 6.25 mcg of liothyronine and 25 mcg of levothyroxine once a day. Children 6 to 12 months of age—At first, 6.25 mcg of liothyronine and 25 mcg of levothyroxine once a day. Doses may be increased as needed. However, the dose is usually not more than 9.35 mcg of liothyronine and 37.5 mcg of levothyroxine once a day. Children 1 to 5 years of age—At first, 9.35 mcg of liothyronine and 37.5 mcg of levothyroxine once a day. Doses may be increased as needed. However, the dose is usually not more than 12.5 mcg of liothyronine and 50 mcg of levothyroxine once a day. Children 6 to 12 years of age—At first, 12.5 mcg of liothyronine and 50 mcg of levothyroxine once a day. Doses may be increased as needed. However, the dose is usually not more than 18.75 mcg of liothyronine and 75 mcg of levothyroxine once a day. Children over 12 years of age—The usual dose is 18.75 mcg of liothyronine and 75 mcg of levothyroxine once a day. Doses may be increased as needed .Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store in the refrigerator. Do not freeze.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using This Medicine
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests will be needed to check for unwanted effects .
Liotrix should not be used for the treatment of obesity or for the purpose of losing weight. This medicine is ineffective for weight reduction and when taken in larger amount, it may cause more serious medical conditions .
Hypothyroidism can sometimes cause infertility in men and women. Liotrix should not be used for the treatment of infertility unless it is caused by hypothyroidism .
Call your doctor right away if you start to have chest pain, fast or irregular heartbeat, excessive sweating, heat intolerance, nervousness, or any other unusual medical condition .
For patients with diabetes, it is very important that you keep track of your blood or urine sugar levels as instructed by your doctor. Check with your doctor immediately if you notice any changes in your sugar levels .
A temporary loss of hair may occur during the first few months of liotrix therapy. Ask your doctor about this if you have any concerns .
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not determined
Chest pain constipation depressed mood difficulty in moving discouragement dryness of the eye dry skin and hair fast, irregular, pounding, or racing heartbeat or pulse fear, nervousness feeling cold feeling sad or empty fever headache hives or welts hoarseness or husky voice increased sweating increased weight increase in blood pressure irritability irritation itching skin joint pain, stiffness or swelling lack of appetite lack or loss of strength loss of interest or pleasure muscle aching or cramping muscle pain or stiffness nausea redness of skin shakiness in legs, arms, hands, feet shortness of breath skin rash sleeplessness slowed heartbeat sluggishness swelling of eyelids, face, lips, hands, or feet swollen joints tightness in chest tiredness trembling or shaking of hands or feet trouble concentrating troubled breathing or swallowing trouble sleeping unable to sleep unusual tiredness or weakness weight gain wheezingSome side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not determined
Hair loss, thinning of hairOther side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.