Naproxen/Esomeprazole (By mouth)
na-PROX-en, es-oh-MEP-ra-zole mag-NEE-zee-um
Analgesic, Antirheumatic (About this – PubMed Health)
Uses of This Medicine
Naproxen and esomeprazole combination is used to relieve the symptoms of ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. It is used for patients who have an increased risk for stomach ulcers and who need to take a nonsteroidal anti-inflammatory drug (NSAID) for arthritis or ankylosing spondylitis.
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain, inflammation, swelling, stiffness, and joint pain. Esomeprazole is a proton pump inhibitor (PPI) that is used to treat certain conditions where too much acid is produced in the stomach (eg, duodenal and gastric ulcers).
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Delayed Release Tablet
Your doctor will tell you how much medicine to use. Do not use more than directed.
Take this medicine at least 30 minutes before a meal.
Swallow the tablet whole with water. Do not break, crush, chew, or dissolve it.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some medicines can affect how naproxen/esomeprazole works. Tell your doctor if you are using any of the following:Cholestyramine, cilostazol, clopidogrel, cyclosporine, diazepam, digoxin, erlotinib, ketoconazole, lithium, methotrexate, mycophenolate mofetil, probenecid, rifampin, St John’s wort, tacrolimus, voriconazole Blood pressure medicines Blood thinner (including dicumarol, heparin, warfarin) Diuretic (water pill) Iron supplements SSRI medicine to treat depression Medicine to treat HIV infection (including atazanavir, nelfinavir, saquinavir, ritonavir) Steroids (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to naproxen, esomeprazole, or to similar medicines. Do not use this medicine right before or right after you have heart bypass surgery.
Tell your doctor if you have kidney disease, liver disease, asthma, bleeding problems, Crohn disease, ulcers or other stomach problems, osteoporosis, heart failure, high blood pressure, or any heart or blood vessel problems.
This medicine may cause the following problems:Increased risk of blood clots, heart attack, or stroke Stomach ulcers or bleeding Kidney or liver problems Low vitamin B12 or magnesium levels Increased risk of broken bones in the hip, wrist, or spine
This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Bloody, black, or tarry stools
Change in how much or how often you urinate, bloody or cloudy urine
Chest pain that may spread, trouble breathing, nausea, unusual sweating, fainting
Numbness or weakness in your arm or leg, or on one side of your body
Severe diarrhea, stomach cramps, fever
Stomach pain, nausea, vomiting, weight loss
Unexplained weight gain, swelling in your hands, ankles, or feet
Unusual bleeding, bruising, or weakness
Vomiting of blood or material that looks like coffee grounds
If you notice these less serious side effects, talk with your doctor:
Mild diarrhea, stomach upset
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.