Micromedex Detailed Drug Information for the Consumer [Internet]. Truven Health Analytics; 1974-2016.
Meclizine, Buclizine, and Cyclizine (Oral route, Parenteral route)
In the US: Antivert, Antivert/25, Atarax, Brintellix, Compazine, Permitil, Prolixin, Ranexa, Torecan, Trilafon, Vistaril, Xyzal, ZyrTEC
Dosage formsTablet Tablet, Extended Release Capsule Liquid Solution Elixir Tablet, Chewable Tablet, Disintegrating Capsule, Liquid Filled Syrup Capsule, Extended Release Suspension
Uses of This Medicine
Some of these preparations are available only with your doctor’s prescription. Others are available without a prescription; however, your doctor may have special instructions on the proper dose of the medicine for your medical condition.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, some of these medicines are used in certain patients to prevent the following medical conditions:Nausea and vomiting following surgery Nausea and vomiting following cancer radiation treatment
Before Using This Medicine
These medicines have not been shown to cause birth defects or other problems in humans. However, studies in animals have shown that buclizine, cyclizine, and meclizine given in doses many times the usual human dose cause birth defects, such as cleft palate.
Although these medicines may pass into breast milk, they have not been reported to cause problems in nursing babies. However, since these medicines tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some patients.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.Amifampridine Amitriptyline Amoxapine Amprenavir Arsenic Trioxide Atazanavir Bepridil Carbamazepine Cisapride Clarithromycin Clomipramine Cobicistat Colchicine Darunavir Desipramine Dofetilide Doxepin Dronedarone Droperidol Fosamprenavir Fosphenytoin Furazolidone Idelalisib Imipramine Indinavir Iproniazid Isocarboxazid Itraconazole Ketoconazole Levomethadyl Linezolid Lopinavir Mesoridazine Methylene Blue Metoclopramide Moclobemide Nefazodone Nelfinavir Nortriptyline Pargyline Phenelzine Phenobarbital Phenytoin Pimozide Piperaquine Posaconazole Procarbazine Protriptyline Rasagiline Rifabutin Rifampin Rifapentine Ritonavir Safinamide Saquinavir Selegiline Sodium Oxybate Sparfloxacin St John’s Wort Terfenadine Thioridazine Tranylcypromine Trimipramine Venlafaxine Ziprasidone
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Abciximab Abiraterone Acecainide Aceclofenac Acemetacin Acenocoumarol Afatinib Ajmaline Alfentanil Alfuzosin Almotriptan Alprazolam Amineptine Amiodarone Amisulpride Amitriptyline Amitriptylinoxide Amobarbital Amoxapine Amtolmetin Guacil Anagrelide Anileridine Apixaban Apomorphine Aprepitant Aprindine Ardeparin Argatroban Aripiprazole Arsenic Trioxide Artemether Asenapine Aspirin Astemizole Azimilide Azithromycin Bedaquiline Bivalirudin Bretylium Bromazepam Bromfenac Brompheniramine Bufexamac Buprenorphine Bupropion Buserelin Buspirone Butabarbital Butorphanol Carbamazepine Carbinoxamine Celecoxib Ceritinib Certoparin Chloral Hydrate Chlordiazepoxide Chloroquine Chlorpheniramine Chlorpromazine Choline Salicylate Cilostazol Ciprofloxacin Citalopram Clarithromycin Clomipramine Clonazepam Clonixin Clopidogrel Clorazepate Clozapine Cocaine Codeine Crizotinib Cyclobenzaprine Cyclosporine Dabigatran Etexilate Dabrafenib Dalteparin Danaparoid Darunavir Dasabuvir Dasatinib Degarelix Delamanid Desipramine Desirudin Deslorelin Desvenlafaxine Dexamethasone Dexibuprofen Dexketoprofen Dexmedetomidine Dextromethorphan Diacetylmorphine Diazepam Dibenzepin Diclofenac Difenoxin Diflunisal Dihydrocodeine Dihydroergotamine Diltiazem Diphenhydramine Diphenoxylate Dipyridamole Dipyrone Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin Doxorubicin Doxorubicin Hydrochloride Liposome Doxylamine Droperidol Drotrecogin Alfa Droxicam Duloxetine Eletriptan Eliglustat Encainide Enflurane Enoxaparin Enzalutamide Eptifibatide Ergotamine Erythromycin Escitalopram Eslicarbazepine Acetate Estazolam Eszopiclone Ethchlorvynol Ethylmorphine Etodolac Etofenamate Etoricoxib Everolimus Felbinac Fenoprofen Fentanyl Fepradinol Feprazone Fingolimod Flecainide Flibanserin Floctafenine Fluconazole Flufenamic Acid Fluoxetine Flurazepam Flurbiprofen Fluvoxamine Fondaparinux Fosaprepitant Foscarnet Fosphenytoin Fospropofol Frovatriptan Gatifloxacin Gemifloxacin Gonadorelin Goserelin Granisetron Halazepam Halofantrine Haloperidol Halothane Heparin Histrelin Hydrocodone Hydromorphone Hydroquinidine Hydroxychloroquine Hydroxytryptophan Hydroxyzine Ibuprofen Ibuprofen Lysine Ibutilide Iloperidone Imipramine Indomethacin Isoflurane Isradipine Ivabradine Ketazolam Ketobemidone Ketoconazole Ketoprofen Ketorolac Lapatinib Lepirudin Leuprolide Levofloxacin Levomethadyl Levomilnacipran Levorphanol Lidoflazine Lithium Lofepramine Lopinavir Lorazepam Lorcainide Lorcaserin Lornoxicam Lovastatin Loxoprofen Lumefantrine Lumiracoxib Meclizine Meclofenamate Mefenamic Acid Mefloquine Melitracen Meloxicam Meperidine Meprobamate Methadone Methotrimeprazine Metrizamide Metronidazole Midazolam Mifepristone Milnacipran Mirtazapine Morniflumate Morphine Morphine Sulfate Liposome Moxifloxacin Nabumetone Nadroparin Nafarelin Nalbuphine Naproxen Naratriptan Nefazodone Nepafenac Nicomorphine Niflumic Acid Nilotinib Nimesulide Nintedanib Nitrazepam Norfloxacin Nortriptyline Octreotide Ofloxacin Ondansetron Opipramol Opium Opium Alkaloids Oxaprozin Oxazepam Oxycodone Oxymorphone Oxyphenbutazone Paliperidone Palonosetron Panobinostat Papaveretum Parecoxib Paregoric Paritaprevir Parnaparin Paroxetine Pasireotide Pazopanib Peginterferon Alfa-2b Pentamidine Pentazocine Pentobarbital Perflutren Lipid Microsphere Phenindione Phenobarbital Phenprocoumon Phenylbutazone Phenytoin Piketoprofen Piritramide Pirmenol Piroxicam Pixantrone Posaconazole Prajmaline Pranoprofen Prasugrel Prazepam Primidone Probucol Procainamide Procarbazine Prochlorperazine Proglumetacin Promethazine Propafenone Propionic Acid Propofol Propoxyphene Propyphenazone Proquazone Protein C Protriptyline Quazepam Quetiapine Quinidine Quinine Ramelteon Ranolazine Remifentanil Reviparin Rifabutin Rifampin Rifapentine Risperidone Rivaroxaban Rizatriptan Rofecoxib Romidepsin Salicylic Acid Salmeterol Salsalate Secobarbital Sematilide Sertindole Sertraline Sevoflurane Sibutramine Simeprevir Simvastatin Sodium Oxybate Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Sodium Salicylate Solifenacin Sorafenib Sotalol Spiramycin St John’s Wort Sufentanil Sulfamethoxazole Sulfinpyrazone Sulindac Sultopride Sumatriptan Sunitinib Suvorexant Tacrolimus Tamoxifen Tapentadol Tedisamil Telavancin Telithromycin Temazepam Tenoxicam Tetrabenazine Thioridazine Tianeptine Tiaprofenic Acid Ticagrelor Ticlopidine Tilidine Tinzaparin Tirofiban Tizanidine Tocophersolan Tolfenamic Acid Tolmetin Topotecan Toremifene Tramadol Trazodone Treprostinil Triazolam Trifluoperazine Trimethoprim Trimipramine Triptorelin Valdecoxib Vandetanib Vardenafil Vasopressin Vemurafenib Venlafaxine Verapamil Vilazodone Vincristine Vincristine Sulfate Liposome Vinflunine Voriconazole Warfarin Zaleplon Ziprasidone Zolmitriptan Zolpidem Zopiclone Zotepine
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Using medicines in this class with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use your medicine, or give you special instructions about the use of food, alcohol, or tobacco.Grapefruit Juice
Other Medical Problems
The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:Asthma, bronchitis, emphysema, or other chronic lung disease—Cyclizine or meclizine may cause serious breathing problems in patients who have any of these conditions. Enlarged prostate or Glaucoma or Intestinal blockage or Urinary tract blockage—Buclizine, cyclizine, or meclizine may make these conditions worse. Heart failure—Cyclizine may make the condition worse.
Proper Use of This Medicine
This medicine is used to relieve or prevent the symptoms of motion sickness or vertigo (dizziness caused by other medical problems). Take it only as directed. Do not take more of it or take it more often than stated on the label or ordered by your doctor. To do so may increase the chance of side effects.
The dose medicines in this class will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For buclizineFor oral dosage form (chewable tablets): To prevent motion sickness: Adults and teenagers—The usual dose is 50 milligrams (mg) thirty minutes before travel. The dose may be repeated every four to six hours if needed. Not more than 150 mg should be taken in one day. Children—Dose must be determined by your doctor.
For cyclizineFor oral dosage form (tablets): To prevent and treat motion sickness: Adults and teenagers—The usual dose is 50 milligrams (mg) thirty minutes before travel. The dose may be repeated every four to six hours if needed. Not more than 200 mg should be taken in one day. Children 6 to 12 years of age—The usual dose is 25 mg thirty minutes before travel. The dose may be repeated every six to eight hours if needed. Not more than 75 mg should be taken in one day. Children up to 6 years of age—Use and dose must be determined by your doctor. For injection dosage form: To prevent and treat motion sickness: Adults and teenagers—The usual dose is 50 mg injected into a muscle every four to six hours as needed. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 mg per kilogram (0.45 mg per pound) of body weight injected into a muscle three times a day as needed.
For meclizineFor oral dosage forms (tablets and chewable tablets): To prevent and treat motion sickness: Adults and children 12 years of age or older—The usual dose is 25 to 50 milligrams (mg) one hour before travel. The dose may be repeated every twenty-four hours as needed. Children up to 12 years of age—Use and dose must be determined by your doctor. To prevent and treat vertigo (dizziness): Adults and children 12 years of age or older—The usual dose is 25 to 100 mg a day as needed, divided into smaller doses. Children up to 12 years of age—Use and dose must be determined by your doctor.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Keep out of the reach of children.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using This Medicine
Tell the doctor in charge that you are taking this medicine before you have any skin tests for allergies. The results of the test may be affected by this medicine.
Buclizine, cyclizine, or meclizine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.
This medicine may cause some people to become drowsy or less alert than they are normally Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.
Buclizine, cyclizine, and meclizine may cause dryness of the mouth. For temporary relief use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common or rareBlurred or double vision constipation diarrhea difficult or painful urination dizziness dryness of mouth, nose, and throat fast heartbeat headache loss of appetite nervousness, restlessness, or trouble in sleeping skin rash upset stomach
Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. Buclizine, cyclizine, and meclizine are similar, so any of the above side effects may occur with any of these medicines.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.