Rifampin/Isoniazid (By mouth)
rif-AM-pin, eye-soe-NYE-a-zid
Treats tuberculosis (TB).
Drug classes
Antitubercular Combination (About this – PubMed Health)
Uses
Uses of This Medicine
Rifampin and isoniazid is a combination antibiotic and anti-infective medicine. This combination medication is used to treat tuberculosis (TB). It may be taken alone or with one or more other medicines for TB.
To help clear up your tuberculosis (TB) infection completely, you must keep taking this medicine for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses.
Rifampin and isoniazid combination is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Capsule, Tablet
Your doctor will tell you how much medicine to use. Do not use more than directed.
Rifampin/isoniazid should be taken on an empty stomach, 1 hour before or 2 hours after a meal.
It is important to take this medicine on a regular schedule. Keep taking it even if you are feeling better. Your doctor will tell you when you can stop taking it.
If a dose is missed:
Take the missed dose as soon as possible.
If it is almost time for your next regular dose, wait until then to take your medicine and skip the missed dose.
You should not use two doses at the same time.
How to Store and Dispose of This Medicine:
Store at room temperature in a closed container, away from heat, light, and moisture.
Keep all medicine out of the reach of children.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Do not drink alcohol while taking this medicine.
Rifampin interacts with many other medicines. Make sure your doctor knows all of the medicines that you are taking before taking rifampin. The doses of the other medicines may have to be changed while you are taking rifampin.
Some types of fish and cheese may cause reactions such as flushing, chills, headache, slow or pounding heartbeat, and nausea and vomiting.
Birth control pills may not work if you take them with this medicine. A different kind of birth control should be used; check with your doctor.
When Not To Use
You should not use this medicine if you have ever had an allergic reaction to rifampin or isoniazid. Avoid using this medicine if you have liver disease.
Warnings
If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
Be sure to see your doctor regularly while you are taking this medicine. Reschedule any appointments you miss.
Do not stop taking this medicine without talking to your doctor.
Your urine, stool, saliva (spit), sweat, and tears may turn a red-orange color when you take this medicine.
Soft contact lenses may be permanently stained by rifampin. You may not want to wear them while taking this medicine.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Nausea and vomiting with extreme tiredness
Numbness, pain, or tingling in arms or legs
Unsteadiness or weakness
Bloody or very dark urine
If you notice these less serious side effects, talk with your doctor:
Stomach upset or cramping
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
IsonaRif, Rifamate
There may be other brand names for this medicine.