Glucarpidase (By injection)
Antidote, Methotrexate Rescue (About this – PubMed Health)
Uses of This Medicine
This medicine is to be given only by or under the direct supervision of a doctor.
Other uses (PubMed Health)
How To Use
Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
A nurse or other health provider will give you this medicine.
Drink extra fluids so you will urinate more often and help prevent kidney problems.
If a dose is missed:
Only 1 dose of this medicine will be given.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Leucovorin should not be given within 2 hours of this medicine.
When Not To Use
You should not receive this medicine if you have had an allergic reaction to glucarpidase.
Make sure your doctor knows if you are pregnant or breastfeeding.
Tell your nurse or doctor right away if you have an infusion reaction. Some symptoms might be fever, chills, rash, hives, itching, headache, tingling, or numbness. You might also feel hot, or your throat may feel tight or swollen.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Lightheadedness, dizziness, or fainting
If you notice these less serious side effects, talk with your doctor:
Warmth or redness in your face, neck, arms, or upper chest
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.