Collagenase, Clostridium histolyticum (By injection)
KOL-a-jen-ase klos-TRID-ee-um his-toe-LIT-ik-um
Treats Dupuytren contracture and Peyronie disease.
Tissue Permeability Modifier (About this – PubMed Health)
Uses of This Medicine
Collagenase clostridium histolyticum injection is used to treat Dupuytren’s contracture with a palpable cord. It is also used to treat Peyronie’s disease with a palpable plaque and curvature deformity in men.
This medicine is to be given only by or under the supervision of your doctor.
Other uses (PubMed Health)
How To Use
A nurse or other health provider will give you this medicine.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
When Not To Use
This medicine may cause the following problems:Tendon rupture or other serious injury to the affected finger or hand Fracture of or other serious injury to the penis Bleeding or bruising at the injection site
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Fever or chills
Severe bruising or bleeding at the injection site
Peyronie disease: Popping sound or sensation in an erect penis, sudden loss of an erection or painful erection, blood in your urine or trouble urinating
If you notice these less serious side effects, talk with your doctor:
Redness, pain, itching, bleeding, swelling, or tenderness at or around the injection site
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.