Micromedex Detailed Drug Information for the Consumer [Internet]. Truven Health Analytics; 1974-2016.
Colistin, Neomycin, Thonzonium, and Hydrocortisone (Otic route)
koe-LIS-tin SUL-fate, nee-oh-MYE-sin SUL-fate, hye-droe-KOR-ti-sone AS-e-tate, thon-ZOE-nee-um BROE-mideBrand Name(s)
In the US: Coly-Mycin S, Cortisporin TC
In Canada: Coly-Mycin
Dosage forms
Suspension
Classifications
Therapeutic: Anti-Infective/Anti-Inflammatory Combination; Pharmacologic: Hydrocortisone; Chemical: Neomycin
Uses of This Medicine
Colistin, neomycin, and hydrocortisone combination contains two antibiotics and a cortisone-like medicine. It is used in the ear to treat infections of the ear canal and to help provide relief from redness, irritation, and discomfort of certain ear problems.
Colistin, neomycin, and hydrocortisone combination is available only with your doctor’s prescription.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Pregnancy
Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Amifampridine Rotavirus Vaccine, LiveUsing this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Alcuronium Aldesleukin Atracurium Bupropion Cidofovir Cisatracurium Colistimethate Sodium Dasabuvir Decamethonium Doxacurium Ethacrynic Acid Fazadinium Foscarnet Furosemide Gallamine Hexafluorenium Metocurine Mivacurium Pancuronium Pipecuronium Piperaquine Pixantrone Rapacuronium Rocuronium Sorafenib Topotecan Tubocurarine VecuroniumUsing this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Alcuronium Atracurium Balofloxacin Besifloxacin Bumetanide Ciprofloxacin Colestipol Enoxacin Fleroxacin Flumequine Gallamine Gatifloxacin Gemifloxacin Hexafluorenium Levofloxacin Licorice Lomefloxacin Metocurine Moxifloxacin Nadifloxacin Norfloxacin Ofloxacin Pazufloxacin Pefloxacin Primidone Prulifloxacin Rifapentine Rufloxacin Saiboku-To Sparfloxacin TosufloxacinOther Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Other ear infection or problem, including punctured eardrum—Use of colistin, neomycin, and hydrocortisone combination may make the condition worse or may increase the chance of side effects Herpes simplex—Use of hydrocortisone may make the condition worseProper Use of This Medicine
Before applying this medicine, thoroughly clean the ear canal and dry it with a sterile cotton applicator.
You may warm the ear drops to body temperature (37 °C or 98.6 °F), but no higher, by holding the bottle in your hand for a few minutes before applying. If this medicine gets too warm, it may break down and not work properly.
To apply this medicine:
Lie down or tilt the head so that the infected ear faces up. Gently pull the earlobe up and back for adults (down and back for children) to straighten the ear canal. Drop the medicine into the ear canal. Keep the ear facing up for about 5 minutes to allow the medicine to coat the ear canal. (For young children and other patients who cannot stay still for 5 minutes, try to keep the ear facing up for at least 1 or 2 minutes.) Your doctor may have inserted a gauze or cotton wick into your ear and may want you to keep the wick moistened with this medicine. Your doctor also may have other directions for you, such as how long you should keep the wick in your ear or when you should return to your doctor to have the wick replaced. If you have any questions about this, check with your doctor.To keep the medicine as germ-free as possible, do not touch the dropper to any surface (including the ear). Also, keep the container tightly closed.
Do not use this medicine for more than 10 days unless otherwise directed by your doctor.
To help clear up your infection completely, keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For otic suspension (ear drops) dosage form: For infections of the ear canal: Adults—Use four drops in the ear every six to eight hours. Children—Use up to three drops in the ear every six to eight hours.Missed Dose
If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using This Medicine
If your symptoms do not improve within 1 week, or if they become worse, check with your doctor immediately.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Itching, skin rash, redness, swelling, or other sign of irritation not present before use of this medicineOther side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.