Micromedex Detailed Drug Information for the Consumer [Internet]. Truven Health Analytics; 1974-2016.
Neomycin, Polymyxin B, and Hydrocortisone (Ophthalmic route)
nee-oh-MYE-sin SUL-fate, pol-ee-MIX-in B SUL-fate, hye-droe-KOR-ti-soneBrand Name(s)
In the US: Cortisporin
Dosage forms
Suspension
Classifications
Therapeutic: Aminoglycoside/Corticosteroid Combination; Pharmacologic: Adrenal Glucocorticoid; Chemical: Neomycin
Uses of This Medicine
Neomycin, polymyxin B, and hydrocortisone is a combination antibiotic and cortisone-like medicine. It is used to treat infections of the eye and to help provide relief from redness, irritation, and discomfort of certain eye problems. It is also used to help prevent permanent damage of certain eye problems.
Neomycin, polymyxin B, and hydrocortisone combination is available only with your doctor’s prescription.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Pregnancy
Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Amifampridine Rotavirus Vaccine, LiveUsing this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Alcuronium Aldesleukin Atracurium Bupropion Cidofovir Cisatracurium Colistimethate Sodium Dasabuvir Decamethonium Doxacurium Ethacrynic Acid Fazadinium Foscarnet Furosemide Gallamine Hexafluorenium Metocurine Mivacurium Pancuronium Pipecuronium Piperaquine Pixantrone Rapacuronium Rocuronium Sorafenib Topotecan Tubocurarine VecuroniumUsing this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Alcuronium Atracurium Balofloxacin Besifloxacin Bumetanide Ciprofloxacin Cisatracurium Colestipol Doxacurium Enoxacin Fazadinium Fleroxacin Flumequine Gallamine Gatifloxacin Gemifloxacin Hexafluorenium Levofloxacin Licorice Lomefloxacin Metocurine Mivacurium Moxifloxacin Nadifloxacin Norfloxacin Ofloxacin Pancuronium Pazufloxacin Pefloxacin Pipecuronium Primidone Prulifloxacin Rapacuronium Rifapentine Rocuronium Rufloxacin Saiboku-To Sparfloxacin Tosufloxacin Tubocurarine VecuroniumOther Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Any other eye infection or condition or Glaucoma—Use of neomycin, polymyxin B, and hydrocortisone ophthalmic drops may make the condition worse Cataract surgery, recent—Use of neomycin, polymyxin B, and hydrocortisone ophthalmic drops may delay healing or cause other problemsProper Use of This Medicine
The bottle is only partially full to provide proper drop control.
To use:
First, wash your hands. Then tilt the head back and pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close the eyes. Do not blink. Keep the eyes closed for 1 or 2 minutes to allow the medicine to come into contact with the infection. If you think you did not get the drop of medicine into your eye properly, use another drop. To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.To help clear up your infection completely, keep using this medicine for the full time of treatment, even if your symptoms have disappeared. Do not miss any doses.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For eye infection: For ophthalmic suspension dosage forms: Adults—One or two drops every three or four hours. Children—Use and dose must be determined by your doctor.Missed Dose
If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using This Medicine
If you will be using this medicine for more than 10 days, your doctor should check your eyes at regular visits.
If your symptoms do not improve within a few days, or if they become worse, check with your doctor.
If a rash or allergic reaction develops, you should check with your doctor right away.
You should not let anyone else use your medicine. It could cause infection to spread.
Do not use any leftover medicine for future eye problems without checking with your doctor first. This medicine should not be used on many different kinds of infection.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Stop taking this medicine and get emergency help immediately if any of the following effects occur:
Rare
Fainting lightheadedness (sudden and severe) shortness of breath or trouble breathing (severe) swelling around faceCheck with your doctor immediately if any of the following side effects occur:
More common
Itching, rash, redness, swelling, or other sign of irritation not present before use of this medicineRare
Blurred vision or other change in vision delayed healing of eye infectionSome side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Burning or stinging when applying medicineOther side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.