Isosorbide Dinitrate/Hydralazine (By mouth)
eye-soe-SOR-bide dye-NYE-trate, hye-DRAL-a-zeen hye-droe-KLOR-ide
Treats heart failure.
Drug classes
Antianginal, Coronary Vasodilator (About this – PubMed Health)
Uses
Uses of This Medicine
Isosorbide dinitrate and hydralazine combination is used to treat heart failure in black patients.
Isosorbide dinitrate belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its work load.
Hydralazine works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its work load.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Do not use this medicine together with riociguat or medicine for erectile dysfunction, including avanafil, sildenafil, tadalafil, or vardenafil.
Some medicines can affect how this medicine works. Tell your doctor if you are using a blood pressure or beta-blocker medicine, including lisinopril, metoprolol, or propranolol.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to nitrates, isosorbide, or hydralazine.
Warnings
Tell your doctor if you are pregnant or breastfeeding, or if you have low blood pressure or heart disease.
This medicine may cause the following problems:
Symptoms of lupus (may go away when you stop using the medicine) Worsening heart diseaseThis medicine may make you dizzy or lightheaded. This is more likely to happen if you are dehydrated. Drink plenty of fluids to help prevent dehydration. Stand up slowly to help prevent dizziness. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. These symptoms may be worse if you drink alcohol.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Chest pain, fast or pounding heartbeat
Lightheadedness, fainting
Numbness, tingling, or burning pain in your hands, arms, legs, or feet
If you notice these less serious side effects, talk with your doctor:
Dizziness
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Bidil
There may be other brand names for this medicine.