Eliglustat (By mouth)
el-i-GLOO-stat
Treats type I Gaucher disease.
Drug classes
Endocrine-Metabolic Agent (About this – PubMed Health)
Uses
Uses of This Medicine
Eliglustat is used for the long-term treatment of type 1 Gaucher disease.
Type 1 Gaucher disease is a disease you get from both your parents. People with type 1 Gaucher disease lack an enzyme (naturally occurring substance in your body) that breaks down a chemical in your body called glucosylceramide. Too much glucosylceramide causes liver and spleen enlargement, changes in the blood, and bone disease. Eliglustat works by stopping the body from making glucosylceramide.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Capsule
Your doctor will tell you how much medicine to use. Do not use more than directed.
Swallow the capsule whole with water. Do not crush, break, chew, or open it.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
This medicine may cause changes in heart rhythm when used with certain other medicines. Tell your doctor if you are using any of the following:
Colchicine, dabigatran, digoxin, metoprolol, ranitidine, rifampin, St John’s wort Medicine for heart rhythm problems (amiodarone, procainamide, quinidine, sotalol) Medicine to treat depression (amitriptyline, imipramine, nortriptyline, paroxetine) Medicine to treat fungal infection (fluconazole, ketoconazole, terbinafine) Phenothiazine medicine (chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine) Seizure medicine (carbamazepine, phenobarbital, phenytoin)If you have been using imiglucerase, velaglucerase alfa, or taliglucerase alfa, you may begin eliglustat 24 hours after you take the last dose of these medicines.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
When Not To Use
This medicine is generally considered safe for most people. Talk to your doctor if you have concerns.
Warnings
Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart failure, heart rhythm problems (including long QT syndrome, slow heartbeat), or a history of heart attack.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Fainting or dizziness
Fast, slow, or uneven heartbeat
If you notice these less serious side effects, talk with your doctor:
Diarrhea, nausea, gas, heartburn, stomach pain or upset
Tiredness or weakness
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Cerdelga
There may be other brand names for this medicine.