Micromedex Detailed Drug Information for the Consumer [Internet]. Truven Health Analytics; 1974-2016.
Bumetanide (Injection route)
bue-MET-a-nideBrand Name(s)
In the US: Bumex
Dosage forms
Solution
Classifications
Therapeutic: Cardiovascular Agent; Pharmacologic: Diuretic, Loop
Warning
Injection route (Solution)
Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient’s needs .
Uses of This Medicine
Bumetanide belongs to a group of medicines called loop diuretics or “water pills.” Bumetanide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .
This medicine is available only with your doctor’s prescription .
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Pregnancy
Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Arsenic Trioxide Bepridil Digitoxin Dofetilide Droperidol Foscarnet Ketanserin Levomethadyl Lithium Metolazone SotalolUsing this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Aceclofenac Acemetacin Alacepril Amtolmetin Guacil Aspirin Benazepril Bromfenac Bufexamac Captopril Celecoxib Choline Salicylate Cilazapril Clonixin Delapril Dexibuprofen Dexketoprofen Dibekacin Diclofenac Diflunisal Dipyrone Droxicam Enalapril Enalaprilat Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Floctafenine Flufenamic Acid Flurbiprofen Fosinopril Germanium Ginseng Gossypol Ibuprofen Ibuprofen Lysine Imidapril Indomethacin Kanamycin Ketoprofen Ketorolac Licorice Lisinopril Lornoxicam Loxoprofen Lumiracoxib Meclofenamate Mefenamic Acid Meloxicam Moexipril Morniflumate Nabumetone Naproxen Neomycin Nepafenac Niflumic Acid Nimesulide Oxaprozin Oxyphenbutazone Parecoxib Pentopril Perindopril Phenylbutazone Piketoprofen Piroxicam Proglumetacin Propionic Acid Propyphenazone Proquazone Quinapril Ramipril Rofecoxib Salicylic Acid Salsalate Sodium Salicylate Spirapril Streptomycin Sulindac Temocapril Tenoxicam Tiaprofenic Acid Tolfenamic Acid Tolmetin Trandolapril Valdecoxib ZofenoprilOther Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Anuria (not able to form urine) or Liver disease, severe (e.g., hepatic coma)—Should not use in patients with these conditions . Dehydration or Gout or Hearing problems or Hyperuricemia (high uric acid in the blood) or Hypocalcemia (low calcium in the blood) or Hypokalemia (low potassium in the blood) or Hypomagnesemia (low magnesium in the blood) or Hypovolemia (low blood volume) or Thrombocytopenia (low platelets in the blood)—Use with caution. This medicine may make these conditions worse . Diabetes—This medicine may increase the amount of sugar in the blood . Kidney disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body .Proper Use of This Medicine
A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins .
Precautions While Using This Medicine
Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to another medicine that works the same way. If you have any concerns about this, talk to your doctor .
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Abdominal pain blurred vision confusion decreased urine output dizziness drowsiness dry mouth fast or irregular heartbeat flushed, dry skin fruit-like breath odor headache increased hunger increased thirst increased urination irritability joint pain, stiffness, or swelling loss of appetite loss of mental alertness lower back, side, or stomach pain mood or mental changes muscle pain or cramps nausea or vomiting numbness or tingling in the hands, feet, or lips shortness of breath sweating swelling of face, hands, feet, ankles, or lower legs troubled breathing unexplained weight loss unusual tiredness or weakness weak pulseRare
Agitation back pain black, tarry stools bleeding gums blood in the urine or stools chest pain convulsions (seizures) deep or fast breathing with dizziness dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly fever hallucinations hives increase in heart rate increased blood pressure numbness of feet, hands, and around the mouth pinpoint red spots on the skin rapid breathing stiff neck sunken eyes trembling, jerking of hands unusual bleeding or bruising weight gain wrinkled skinGet emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Difficulty breathing pain in chest, groin, or legs, especially the calves severe, sudden headache slurred speech sudden loss of coordination sudden, severe weakness or numbness in the arm or leg sudden, unexplained shortness of breath tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area unusual drowsiness, dullness, or feeling of sluggishness vision changesSome side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Rare
Decreased interest in sexual intercourse diarrhea difficulty with moving ear discomfort feeling of constant movement of self or surroundings inability to have or keep an erection itching skin loss in sexual ability, desire, drive, or performance muscle or bone pain muscle stiffness nipple tenderness pain, swelling, or redness in joints rash sensation of spinning shorter than usual time to ejaculation of semen trouble with hearing upset stomachOther side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.