Leuprolide/Norethindrone (By injection)
LOO-proe-lide AS-e-tate, nor-ETH-in-drone AS-e-tate
Treats pain caused by endometriosis.
Uses
Uses of This Medicine
Leuprolide injection and norethindrone tablets are used together to treat pain caused by endometriosis. This combination is also used to prevent the symptoms of endometriosis from occurring again. This medicine should be used no longer than 12 months.
Leuprolide injection is a synthetic (man-made) hormone that is similar to a natural hormone that is produced in the brain. It decreases the amount of estrogen in the body and helps treat endometriosis. Norethindrone is a synthetic (man-made) progestin hormone that is used to treat thinning of the bones caused by leuprolide.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Lupaneta Pack® is a kit that contains 2 medicines that work together.
Injection:
Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles. A nurse or other health provider will give you this medicine. This is a long-acting medicine that is given once a month or once every 3 months, for up to 6 months of treatment.Tablet:
Your doctor will tell you how much medicine to use. Do not use more than directed. Take this medicine every day while you are being treated with the injection medicine, for up to 6 months.Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some medicines can affect how leuprolide works. Tell your doctor if you are using medicine to treat seizures or steroid medicine (such as hydrocortisone, methylprednisolone, prednisone, prednisolone, or dexamethasone).
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to leuprolide or norethindrone, or if you are pregnant or breastfeeding. You should not receive this medicine if you have liver disease, problems caused by blood clots, or a history of breast cancer or other hormone-sensitive cancer.
Warnings
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control that does not contain hormones.
Tell your doctor if you have kidney problems, osteoporosis, migraine headaches, or a history of seizures, depression, asthma, or allergies. Tell your doctor if you smoke or drink alcohol regularly. Tell your doctor if you have risk factors for heart attack or stroke, such as high blood pressure, diabetes, heart disease, high cholesterol, or family history of blood clots.
This medicine may cause the following problems:
Weaker bones, which may lead to osteoporosis DepressionEndometriosis symptoms may get worse for a short time when you first start using this medicine. These symptoms should get better as your body gets used to the medicine.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Rapid weight gain, swelling in your hands, ankles, or feet
Seizures
Severe depression, loss of interest in usual activities, trouble concentrating, mood swings
Sudden loss of vision, double vision, bulging eyes, migraine headache
Unusual or severe bone or back pain
If you notice these less serious side effects, talk with your doctor:
Hot flashes, warmth or redness in your face, neck, arms, or upper chest
Redness, pain, swelling, or itching where the shot was given
Trouble sleeping
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Lupaneta Pack
There may be other brand names for this medicine.