Lisinopril/Hydrochlorothiazide (By mouth)
Uses of This Medicine
Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.
Lisinopril is an angiotensin converting enzyme (ACE) inhibitor. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, lisinopril relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some foods and medicines can affect how lisinopril/hydrochlorothiazide works. Tell your doctor if you are using any of the following:Aliskiren, cholestyramine, colestipol, everolimus, lithium, sirolimus, temsirolimus Another blood pressure medicine, including an angiotensin receptor blocker (ARB) Insulin or oral diabetes medicine NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, or naproxen) Steroid medicine (including hydrocortisone, methylprednisolone, prednisolone, prednisone)
Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to lisinopril, hydrochlorothiazide, another ACE inhibitor, or a sulfa drug, or if you are pregnant.
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, diabetes, heart failure, heart or blood vessel disease, high cholesterol, gout, lupus or a similar disorder, trouble urinating, or a history of allergies or asthma.
This medicine may cause the following problems:Angioedema (severe swelling) Serious liver problems Kidney problems Glaucoma
This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy.
Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
Tell any doctor or dentist who treats you that you are using this medicine.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Change in how much or how often you urinate
Confusion, weakness, uneven heartbeat, trouble breathing, numbness in your hands, feet, or lips
Lightheadedness, dizziness, fainting
Severe stomach pain (with or without nausea or vomiting)
If you notice these less serious side effects, talk with your doctor:
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
There may be other brand names for this medicine.