Nadolol/Bendroflumethiazide (By mouth)

NAY-doe-lol, ben-droe-floo-me-THYE-a-zide

Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine contains a beta-blocker and a thiazide diuretic (water pill).

Drug classes

Beta-Adrenergic Blocker, Nonselective/Thiazide Combination (About this – PubMed Health)

Uses

Uses of This Medicine

Nadolol and bendroflumethiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Nadolol is a beta-blocker. It works by affecting the response to some nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart .

Bendroflumethiazide is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure .

This medicine is available only with your doctor’s prescription .

Other uses (PubMed Health)

How To Use

Tablet

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Carefully follow your doctor’s instructions about any special diet.

If a dose is missed:

Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Make sure your doctor knows if you are using amphotericin B (Fungizone®), a calcium supplement, diazoxide (Hyperstat®, Proglyceum®), digoxin (Lanoxin®), lithium (Eskalith®, Lithobid®), methenamine (Hiprex®, Urex®), reserpine, other blood pressure medicine (such as atenolol, metoprolol, propranolol, Bystolic®, Tenormin®), another diuretic (water pills, such as furosemide, Lasix®), insulin, or diabetes medicine that you take by mouth (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®). Tell your doctor if you are also using a steroid (such as hydrocortisone, methylprednisolone, prednisolone, prednisone), a blood thinner (such as warfarin, Coumadin®, Jantoven®), medicine to treat gout (such as allopurinol, colchicine, probenecid, Benemid®, Zyloprim®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), or an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, Parnate®).

If you are also taking cholestyramine (Questran®) or colestipol (Colestid®), take Corzide® at least 1 hour before or 4 to 6 hours after these medicines.

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.

When Not To Use

Do not use this medicine if you have had an allergic reaction to nadolol, bendroflumethiazide, or a sulfonamide (sulfa) drug. Do not use this medicine if you are not able to urinate, or if you have asthma or certain heart problems. Talk with your doctor about what these heart problems are.

Warnings

Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart failure, heart disease, diabetes, gout, lung problems (such as chronic bronchitis or emphysema), lupus, mineral imbalance (such as high calcium or low magnesium, potassium, or sodium in the blood), thyroid problems, or a history of allergies or asthma.

This medicine may worsen the symptoms of heart failure in some patients. Tell your doctor right away if you have trouble breathing, uneven heartbeat, rapid weight gain, or swelling of the face, fingers, feet, or lower legs.

Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

This medicine may make you dizzy, drowsy, or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.

Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in normal range. You may have to take blood pressure medicine for the rest of your life.

Make sure any doctor or dentist who treats you knows that you are using this medicine.

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Confusion, weakness, or muscle twitching

Dry mouth, increased thirst, muscle cramps, nausea or vomiting, uneven heartbeat

Fast, very slow, pounding, or uneven heartbeat

Lightheadedness, dizziness, or fainting

Swelling in your hands, ankles, or feet, rapid weight gain

Trouble breathing, cold sweat, or bluish-colored skin

Unusual tiredness or weakness, restlessness

Worsening chest pain

If you notice these less serious side effects, talk with your doctor:

Mild dizziness or tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

More side effects of this drug

Brand names include

Corzide, Corzide 40/5, Corzide 80/5

There may be other brand names for this medicine.