Metoprolol/Hydrochlorothiazide (By mouth)
met-oh-PROE-lol TAR-trate, hye-droe-klor-oh-THYE-a-zide
Treats high blood pressure. This medicine is a combination of a beta-blocker and a diuretic (water pill).
Drug classes
Beta-Adrenergic Blocker, Cardioselective/Thiazide Combination, Beta-Adrenergic Blocker/Thiazide Combination (About this – PubMed Health)
Uses
Uses of This Medicine
Metoprolol and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Metoprolol is a beta-blocker. It works by affecting the response to some nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.
Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Tablet, Long Acting Tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Tablet: Take it with a meal or just after a meal.
Extended-release tablet: Take it with or without food. Swallow the extended-release tablet whole. Do not crush, break, or chew it.
Missed dose: If you miss a dose or forget to use your medicine, skip the missed dose. Never take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some foods and medicines can affect how metoprolol/hydrochlorothiazide works. Tell your doctor if you use the following:
Cholestyramine, cimetidine, clonidine, colestipol, digoxin, diphenhydramine, fluoxetine, hydroxychloroquine, lithium, methyldopa, paroxetine, propafenone, quinidine, reserpine, ritonavir, terbinafine, thioridazine Insulin or diabetes medicine MAO inhibitor (MAOI) NSAID pain or arthritis medicine (such as aspirin, diclofenac, indomethacin, naproxen) Steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone)Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.
Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to metoprolol, hydrochlorothiazide, or sulfa drugs.
Warnings
Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, heart rhythm problems (such as bradycardia), glaucoma, gout, diabetes, lupus, an overactive thyroid, pheochromocytoma, trouble urinating, or a history of asthma or lung disease.
This medicine may cause new or worsening heart failure.
Do not stop using this medicine suddenly without asking your doctor, or you could develop life-threatening heart problems.
Tell any doctor or dentist who treats you that you are using this medicine, especially before you have any type of surgery.
This medicine may cause you to feel dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you are dizzy or lightheaded.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blistering, peeling, red skin rash
Change in how much or how often you urinate
Chest pain that may spread, nausea, unusual sweating, fainting
Confusion, weakness, and muscle twitching
Dry mouth, increased thirst, or muscle cramps
Eye pain, vision changes, seeing halos around lights
Lightheadedness, dizziness, or fainting
Slow, fast, pounding, or uneven heartbeat
Sudden and severe stomach pain, nausea, or vomiting
Swelling in your hands, feet, ankles, or legs, tiredness
Trouble breathing or wheezing
If you notice these less serious side effects, talk with your doctor:
Diarrhea, constipation, loss of appetite, or stomach upset
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Dutoprol, Lopressor HCT
There may be other brand names for this medicine.