Probenecid/Colchicine (By mouth)
proe-BEN-e-sid, KOL-chi-seen
Treats gout and gouty arthritis.
Drug classes
Antigout (About this – PubMed Health)
Uses
Uses of This Medicine
Probenecid and colchicine combination is used to treat gout or gouty arthritis.
The probenecid in this medicine helps to prevent gout attacks by removing extra uric acid from the body. The colchicine in this medicine also helps to prevent gout attacks. Although colchicine may also be used to relieve an attack of gout, this requires more colchicine than this combination medicine contains. Probenecid and colchicine combination does not cure gout. This medicine will help prevent gout attacks only as long as you continue to take it.
Probenecid and colchicine combination is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Drink 10 to 12 full glasses of liquids each day unless your doctor tells you differently. This will help to prevent kidney stones.
Carefully follow your doctor’s instructions about any special diet.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some foods and medicines can affect how probenecid works. Tell your doctor if you also use any of the following:
Methotrexate Salicylate medicine, such as aspirin, topical medicine to treat pain, acne medicine, or medicine to treat diarrhea, nausea, and vomiting Penicillin, a sulfa drug, or a similar antibiotic Oral medicine for diabetes Sulindac Acetaminophen, indomethacin, naproxen, ketoprofen, meclofenamate Lorazepam RifampinWhen Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to probenecid or colchicine, or if you are pregnant.
Warnings
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
Tell your doctor if you are breastfeeding, or if you have kidney stones, a blood disorder, kidney disease, liver disease, or a history of stomach ulcers.
This medicine may cause the following problems:
Increased gout symptoms, when you first start treatment Kidney stonesTell any doctor or dentist who treats you that you are using this medicine, especially if you are going to have general anesthesia.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blood in the urine, pain when urinating, back pain
Numbness or tingling in your hands or feet
Severe stomach pain, vomiting, or diarrhea
If you notice these less serious side effects, talk with your doctor:
Dizziness
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
