Quinapril/Hydrochlorothiazide (By mouth)
hye-droe-klor-oh-THYE-a-zide, KWIN-a-pril hye-droe-KLOR-ide
Treats high blood pressure. This medicine is a combination of an ACE inhibitor and a diuretic (water pill).
Drug classes
ACE Inhibitor/Thiazide Combination, Antihypertensive, Cardiovascular Agent (About this – PubMed Health)
Uses
Uses of This Medicine
Quinapril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Hypertension may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Quinapril is an angiotensin converting enzyme (ACE) inhibitor. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, quinapril relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
Hydrochlorothiazide is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine which helps lower the blood pressure.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Do not use this medicine together with aliskiren if you have diabetes.
Some medicines can affect how this medicine works. Tell your doctor if you are also using any of the following:
Aliskiren, digoxin, lithium, temsirolimus, tetracycline, or another diuretic (water pill) Diabetes medicine, a medicine to lower cholesterol, an NSAID pain or arthritis medicine (such as aspirin, celecoxib, diclofenac, ibuprofen, naproxen), or a steroid medicine (such as dexamethasone, hydrocortisone, methylprednisolone, prednisone, prednisolone)Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when you use them with this medicine.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to quinapril, hydrochlorothiazide, or a sulfa drug, if you are pregnant or not able to urinate, or if you have a history of angioedema caused by an ACE inhibitor.
Warnings
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, high cholesterol, low blood pressure, diabetes, glaucoma, gout, or a collagen-vascular disease (such as lupus or scleroderma).
This medicine may cause the following problems:
Intestinal swelling Liver or kidney problems Vision problems or glaucomaThis medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Sit or lie down if you feel dizzy. Stand up carefully. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Change in how much or how often you urinate, problems urinating
Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Fever, chills, sore throat, body aches
Lightheadedness, dizziness, fainting
Severe stomach pain
Vision changes or eye pain
If you notice these less serious side effects, talk with your doctor:
Dry cough
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Accuretic
There may be other brand names for this medicine.