Trandolapril/Verapamil (By mouth)
tran-DOE-la-pril, ver-AP-a-mil hye-droe-KLOR-ide
Treats high blood pressure. This medicine contains an ACE inhibitor and a calcium channel blocker (CCB).
Drug classes
ACE Inhibitor/Calcium Channel Blocker Combination (About this – PubMed Health)
Uses
Uses of This Medicine
Trandolapril and verapamil combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering pressure reduces the risk of strokes and heart attacks.
Trandolapril is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, trandolapril relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
Verapamil is a calcium channel blocker (CCB). It affects the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels, lowers blood pressure, and increase the supply of blood and oxygen to the heart.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Long Acting Tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
It is best to take this medicine with food or milk.
Swallow the extended-release tablet whole. Do not crush, break, or chew it.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Do not use this medicine together with aliskiren if you have diabetes.
Some foods and medicines can affect how trandolapril/verapamil works. Tell your doctor if you are using any of the following:
Almotriptan, buspirone, carbamazepine, colchicine, digoxin, doxorubicin, imipramine, lithium, midazolam, phenobarbital, rifampin, St John’s wort, sulfinpyrazone, theophylline Another blood pressure medicine, including an angiotensin receptor blocker (ARB) Diuretics (water pills, such as amiloride, spironolactone, triamterene) HIV medicine (such as ritonavir) Insulin or diabetes medicine Medicine for heart rhythm problems (such as disopyramide, flecainide, quinidine) Medicine to lower cholesterol (such as atorvastatin, lovastatin, simvastatin) Medicine to treat an infection (such as erythromycin, telithromycin) Medicine that weakens your immune system (such as cyclosporine, sirolimus, tacrolimus) NSAID pain or arthritis medicine (such as aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
When Not To Use
This medicine is not right for everyone. Do not use it if you had an allergic reaction to verapamil, trandolapril or another ACE inhibitor, or you are pregnant.
Warnings
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
Tell your doctor if you are breastfeeding, or if you have kidney problems, liver disease, diabetes, heart failure, heart disease, heart rhythm problems (such as PR interval prolongation), or an autoimmune disorder.
This medicine may cause the following problems:
Angioedema (severe swelling) Serious liver problems Kidney problemsThis medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you are dizzy or lightheaded.
Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
Tell any doctor or dentist who treats you that you are using this medicine.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blistering, peeling, red skin rash
Change in how much or how often you urinate
Chest pain that may spread, trouble breathing, nausea, unusual sweating, fainting
Confusion, weakness, uneven heartbeat, numbness or tingling in your hands, feet, or lips
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Fever, chills, sore throat, and body aches
Lightheadedness, dizziness, or fainting
If you notice these less serious side effects, talk with your doctor:
Dry cough
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Tarka
There may be other brand names for this medicine.