Moexipril/Hydrochlorothiazide (By mouth)
hye-droe-klor-oh-THYE-a-zide, moe-EX-i-pril hye-droe-KLOR-ide
Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine is a combination of an angiotensin-converting enzyme (ACE) inhibitor and a diuretic (water pill).
Drug classes
ACE Inhibitor/Thiazide Combination, Antihypertensive, Cardiovascular Agent (About this – PubMed Health)
Uses
Uses of This Medicine
Moexipril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Moexipril is an angiotensin converting enzyme (ACE) inhibitor. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, moexipril relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower blood pressure.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
It is best to take this medicine on an empty stomach, at least 1 hour before meals.
Carefully follow your doctor’s instructions about any special diet. Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
If a dose is missed:
Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Make sure your doctor knows if you use aliskiren (Tekturna®), lithium (Eskalith®, Lithobid®), gold injections (such as sodium aurothiomalate), or a diuretic or water pill (such as amiloride, furosemide, spironolactone, triamterene, Aldactone®, Lasix®). Your doctor will need to know if you use insulin or a diabetes medicine that you take by mouth (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®) or a steroid medicine (such as dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone, Medrol®).
Tell your doctor if you use allopurinol (Purinol®, Zyloprim®), guanabenz (Wytensin®), norepinephrine, propantheline (Pro-Banthine®), tetracycline (Sumycin®), tubocurarine, medicine to lower your cholesterol (such as cholestyramine, colestipol, Colestid®, Questran®), or an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®).
Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.
Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.
When Not To Use
Do not use this medicine if you have had an allergic reaction to moexipril, hydrochlorothiazide, or sulfa drugs. Do not use this medicine if you are pregnant or if you have severe kidney disease, are not able to urinate, or have a history of angioedema (swelling of the hands, face, mouth, or throat) after receiving an ACE inhibitor. Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes.
Warnings
It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
Make sure your doctor knows if you are breastfeeding or if you have kidney problems, liver disease, congestive heart failure, body swelling, heart or blood vessel disease, low blood pressure, low blood volume, high cholesterol, or mineral imbalance (such as high or low calcium, magnesium, potassium, or sodium in the blood). Tell your doctor if you have diabetes, glaucoma, gout, lupus, a collagen-vascular disease (such as scleroderma), or a history of asthma.
Call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of intestinal angioedema.
This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine. It could also happen if you have diarrhea or vomiting, you sweat heavily, or you do not drink enough water and become dehydrated. If you faint, stop using this medicine and call your doctor right away.
This medicine may make you dizzy or drowsy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
Check with your doctor right away if you have upper stomach pain, pale stools, dark urine, loss of appetite, nausea, unusual tiredness, or yellow eyes or skin. These could be symptoms of a serious liver problem.
Check with your doctor if you have a fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cell counts.
Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
Check with your doctor immediately if you have blurred vision, difficulty in reading, eye pain, or any other change in vision while taking this medicine.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
This medicine may be less effective in black patients. Black patients also have an increased risk of swelling of the hands, arms, face, mouth, or throat.
Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in normal range. You may have to take blood pressure medicine for the rest of your life.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Changes in vision
Change in how much or how often you urinate, problems urinating
Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, or pain in your upper stomach, yellow skin or eyes
Dry mouth, increased thirst, or muscle cramps
Fever, chills, sore throat
Lightheadedness, dizziness, fainting
Rapid weight gain, swelling in your face, tongue, hands, ankles, or feet
Severe stomach pain (with or without nausea)
Unusual tiredness or weakness
If you notice these less serious side effects, talk with your doctor:
Dry cough
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Uniretic
There may be other brand names for this medicine.