Conjugated Estrogens/Medroxyprogesterone (By mouth)

KON-joo-gay-ted ES-troe-jenz, me-drox-ee-proe-JES-ter-one AS-e-tate

Treats hot flashes and vaginal dryness from menopause. Prevents osteoporosis after menopause. This medicine is a combination of 2 hormones.

Drug classes

Estrogen/Progestin Combination (About this – PubMed Health)

Uses

Uses of This Medicine

Conjugated estrogens and medroxyprogesterone acetate combination is used to treat moderate to severe hot flashes, dryness in and around the vagina, and other symptoms of menopause. This medicine is also used to prevent osteoporosis (thinning of the bones) after menopause.

This medicine is available only with your doctor’s prescription.

Other uses (PubMed Health)

How To Use

Tablet

Your doctor will tell you how much medicine to use. Do not use more than directed.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Some medicines and foods can affect how this medicine works. Tell your doctor if you are taking any of the following:

Carbamazepine, phenobarbital Clarithromycin, erythromycin Itraconazole, ketoconazole Rifampin Ritonavir St John’s wort Thyroid medicine

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

When Not To Use

This medicine is not right for everyone. Do not use it if you had an allergic reaction to estrogen or progestin, or you are pregnant or have unusual vaginal bleeding not checked by a doctor. Do not use this medicine if you have a history of liver disease, breast cancer, blood clots or clotting problems, heart attack, or stroke, or you had a hysterectomy.

Warnings

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

Tell your doctor if you are breastfeeding or if you have endometriosis, asthma, diabetes, epilepsy, heart failure, high blood pressure, high cholesterol, kidney disease, lupus, migraine headaches, porphyria, or thyroid problems. Tell your doctor if you have a history of cancer or serious allergic reactions (such as hereditary angioedema).

This medicine may increase your risk for the following:

Cancer, including breast cancer, especially with long-term use of large doses Heart attack or dementia Stroke or blood clots, especially if you smoke, you have high blood pressure, high cholesterol, or diabetes, or you are overweight

Tell your doctor if you have a sudden, severe headache or vision changes while you are taking this medicine. He may want you to have your eyes checked by an eye doctor.

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. Tell any doctor or dentist who treats you that you are taking this medicine. You may need to stop taking it before you have surgery or if you need to be on bedrest.

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Breast lumps

Chest pain, shortness of breath, or coughing up blood

Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking

Pain in your calf

Severe or unusual vaginal bleeding

Sudden and severe stomach pain, with or without nausea, vomiting, fever, and lightheadedness

Swelling in your face, hands, ankles, or feet

Yellowing of your skin or the whites of your eyes

If you notice these less serious side effects, talk with your doctor:

Breast pain

Depression

Light vaginal bleeding or spotting

Mild stomach pain or cramps

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

More side effects of this drug

Brand names include

Premphase, Prempro, Prempro Low Dose

There may be other brand names for this medicine.