Posaconazole (By injection)

poe-sa-KON-a-zole

Treats or prevents fungus infections.

Drug classes

Antifungal (About this – PubMed Health)

Uses

Uses of This Medicine

Posaconazole injection is used to prevent certain fungus (yeast) infections in patients who have a weakened immune system (eg, hematopoietic stem cell transplant or HSCT recipients, or patients with blood cancers).

This medicine is to be given only by or under the direct supervision of a doctor.

Other uses (PubMed Health)

How To Use

Injectable

Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Do not use this medicine together with atorvastatin, lovastatin, pimozide, quinidine, simvastatin, sirolimus, ergotamine, or dihydroergotamine.

Some medicines can affect how posaconazole works. Tell your doctor if you are using cimetidine, cyclosporine, digoxin, esomeprazole, glipizide, metoclopramide, phenytoin, rifabutin, tacrolimus, vinblastine, vincristine, medicine for HIV/AIDS (atazanavir, efavirenz, fosamprenavir, ritonavir), a sedative medicine (alprazolam, midazolam, triazolam), or blood pressure medicine (diltiazem, felodipine, nicardipine, nifedipine, verapamil).

When Not To Use

This medicine is not right for everyone. You should not receive this medicine if you had an allergic reaction to posaconazole or similar medicines.

Warnings

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or heart rhythm problems (such as QT prolongation).

This medicine may cause the following problems:

Heart rhythm problems Liver problems

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

Fast, slow, pounding, or uneven heartbeat

Severe diarrhea or vomiting

Swelling in your arms or legs

Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

Decreased appetite

Fever or chills

Headache

Mild diarrhea, constipation, nausea, vomiting, stomach pain

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

More side effects of this drug

Brand names include

Noxafil

There may be other brand names for this medicine.