Natalizumab (By injection)

na-ta-LYE-zoo-mab

Treats Crohn disease and multiple sclerosis (MS).

Drug classes

Central Nervous System Agent, Immune Modulator, Immune Suppressant (About this – PubMed Health)

Uses

Uses of This Medicine

Natalizumab injection is used to treat patients with relapsing forms of multiple sclerosis (MS), and patients who have not been helped by other medicines. This medicine will not cure MS, but may delay physical disability and extend the time between relapses.

Natalizumab is also used to treat moderate to severely active Crohn’s disease (CD) in patients who have not been helped by other medicines. This medicine will not cure CD, but may prevent it from occurring again.

This medicine is to be given only by or under the direct supervision of your doctor.

Other uses (PubMed Health)

How To Use

Injectable

Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

A nurse or other health provider will give you this medicine.

This medicine is injected slowly, so the needle will need to remain in place for about an hour.

You will need to stay at the clinic or office for 1 hour after you receive this medicine, to make sure you do not have any serious side effects.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Missed dose:This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Some foods and medicines can affect how natalizumab works. Tell your doctor if you are using medicine that weakens your immune system, such as mitoxantrone, azathioprine, methotrexate, cyclophosphamide, mycophenolate mofetil, cyclosporine, mercaptopurine.

When Not To Use

This medicine is not right for everyone. You should not receive this medicine if you had an allergic reaction to natalizumab or if you have had progressive multifocal leukoencephalopathy (PML).

Warnings

Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, a fever, or any kind of infection. Tell your doctor if you have a weak immune system (may be caused by HIV/AIDS, cancer, or an organ transplant).

This medicine may cause the following problems:

Higher risk for infections Infections of the brain or nervous system, including PML, encephalitis, or meningitis Liver damage

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Make sure any doctor or dentist who treats you knows that you are using this medicine.

You may need to have an MRI scan before you start using this medicine.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

Fever, chills, runny or stuffy nose, cough, sore throat, and body aches

Fever, headache, confusion

Warmth or redness in your face, neck, arms, or upper chest, dizziness

Weakness on one side of your body, clumsiness, trouble seeing or vision changes, confusion, memory problems, unusual behavior

If you notice these less serious side effects, talk with your doctor:

Joint or muscle pain

Diarrhea or upset stomach

Headache

Tiredness

Runny or stuffy nose

Pain, itching, burning, swelling, bleeding, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

More side effects of this drug

Brand names include

Tysabri

There may be other brand names for this medicine.