Alogliptin/Pioglitazone (By mouth)

al-oh-GLIP-tin BEN-zoe-ate, pye-oh-GLI-ta-zone hye-droe-KLOR-ide

Treats type 2 diabetes.

Drug classes

Antidiabetic (About this – PubMed Health)

Uses

Uses of This Medicine

Alogliptin and pioglitazone combination is used with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes. Alogliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. Pioglitazone works by helping your body use insulin better. This medicine does not help patients who have insulin-dependent or type 1 diabetes.

This medicine is available only with your doctor’s prescription.

Other uses (PubMed Health)

How To Use

Tablet

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

Swallow the tablet whole. Do not split, crush, break, or chew it.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Some foods and medicines can affect how alogliptin/pioglitazone works. Tell your doctor if you are using any of the following:

Gemfibrozil Rifampin Insulin or another diabetes medicine

When Not To Use

This medicine is not right for everyone. Do not use it if you had an allergic reaction to alogliptin or pioglitazone.

Warnings

Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are taking this medicine.

Tell your doctor if you have heart failure, kidney disease, or liver disease. Also tell your doctor if you have edema (fluid retention or swelling), macular edema (swelling of the back of the eye), fragile bones, or a history of alcohol abuse, bladder cancer, or pancreas problems.

This medicine may cause the following problems:

Heart failure Pancreatitis Liver damage Increased risk for broken bones Increased risk for bladder cancer if you use this medicine for a long time Low blood sugar levels

Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Blistering, peeling, red skin rash

Blurred vision or other vision changes

Change in how much or how often you urinate, painful urination, lower back or side pain, blood in your urine

Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness

Severe joint pain

Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion

Sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

More side effects of this drug

Brand names include

Oseni

There may be other brand names for this medicine.