Ondansetron (By mouth)

on-DAN-se-tron

Prevents nausea and vomiting.

Drug classes

Antiemetic (About this – PubMed Health)

Uses

Uses of This Medicine

Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.

This medicine is available only with your doctor’s prescription.

Other uses (PubMed Health)

How To Use

Thin Sheet, Liquid, Tablet, Dissolving Tablet

Your doctor will tell you how much medicine to use. Do not use more than directed.

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

To use the disintegrating tablet:

Do not open the blister pack that contains the tablet until you are ready to take it. Make sure your hands are dry. Peel back the foil, then remove the tablet from the blister pack. Do not push the tablet through the foil. Place the tablet on top of your tongue where it will dissolve in seconds. After the tablet has melted, swallow or take a sip of water.

To use the soluble film:

Make sure your hands are clean and dry. Fold the pouch along the dotted line. While still folded, tear the pouch carefully along the edge. Remove the film from the pouch. Place the film on top of your tongue. It will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole. After the film has dissolved, you may swallow with or without water.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the soluble film in the foil pouch until you ready to use it.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Do not use this medicine together with apomorphine.

Some medicines may affect how ondansetron works. Tell your doctor if you are using tramadol, diuretics (water pills), or any other medicine for nausea and vomiting.

When Not To Use

This medicine is not right for everyone. Do not use it if you had an allergic reaction to ondansetron.

Warnings

Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, congestive heart failure, heart rhythm problems (such as prolonged QT interval, slow heartbeat), low magnesium or potassium levels, stomach or bowel problems, or phenylketonuria (PKU).

This medicine may cause heart rhythm problems (such as QT prolongation).

This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Fainting, dizziness, or lightheadedness

Fast, pounding, or uneven heartbeat

Trouble breathing

If you notice these less serious side effects, talk with your doctor:

Constipation or diarrhea

Headache

Tiredness or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

More side effects of this drug

Brand names include

Zofran, Zofran ODT, Zuplenz

There may be other brand names for this medicine.