Collagenase, Clostridium histolyticum (By injection)

KOL-a-jen-ase klos-TRID-ee-um his-toe-LIT-ik-um

Treats Dupuytren contracture and Peyronie disease.

Drug classes

Tissue Permeability Modifier (About this – PubMed Health)

Uses

Uses of This Medicine

Collagenase clostridium histolyticum injection is used to treat Dupuytren’s contracture with a palpable cord. It is also used to treat Peyronie’s disease with a palpable plaque and curvature deformity in men.

This medicine is to be given only by or under the supervision of your doctor.

Other uses (PubMed Health)

How To Use

Injectable

Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into your hand or penis.

A nurse or other health provider will give you this medicine.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Some medicines can affect how collagenase, Clostridium histolyticum works. Tell your doctor if you are using blood thinners, such as high-dose aspirin or warfarin.

When Not To Use

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to collagenase, Clostridium histolyticum, or if you have Peyronie plaque in the penile urethra.

Warnings

Tell your doctor if you are pregnant or breastfeeding, or if you have a blood clotting problem.

This medicine may cause the following problems:

Tendon rupture or other serious injury to the affected finger or hand Fracture of or other serious injury to the penis Bleeding or bruising at the injection site

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Fever or chills

Rapid weight gain, swelling of your hands, ankles, or feet

Severe bruising or bleeding at the injection site

Peyronie disease: Popping sound or sensation in an erect penis, sudden loss of an erection or painful erection, blood in your urine or trouble urinating

If you notice these less serious side effects, talk with your doctor:

Redness, pain, itching, bleeding, swelling, or tenderness at or around the injection site

Swollen, painful, or tender glands in your neck or armpit

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

More side effects of this drug

Brand names include

Xiaflex

There may be other brand names for this medicine.