Clindamycin/Tretinoin (On the skin)

klin-da-MYE-sin FOS-fate, TRET-i-noin

Treats acne. This medicine is a combination of an antibiotic and a retinoid.

Drug classes

Antiacne, Antibacterial, Retinoid Combination (About this – PubMed Health)

Uses

Uses of This Medicine

Clindamycin and tretinoin topical is used to treat acne. It works by killing the bacteria that cause acne and by keeping the skin pores (tiny openings on the skin’s surface) clear.

This medicine is available only with your doctor’s prescription.

Other uses (PubMed Health)

How To Use

Gel/Jelly

Your doctor will tell you how much medicine to use. Do not use more than directed.

You may need to use this medicine for several weeks or months before your skin starts to look better. Extra medicine will not make it work faster.

Use this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.

It is best to use this medicine at bedtime.

Wash your hands with soap and water before and after you use this medicine.

Before you apply this medicine, wash your face with warm water and a mild soap, rinse well, and pat dry.

Apply a thin layer of the medicine to the affected area. Rub it in gently.

Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Missed dose: Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Some medicines can affect how clindamycin/tretinoin works. Tell your doctor if you are taking erythromycin or any muscle relaxant.

Do not use any other medicines on the treated skin areas without asking your doctor. Do not use skin care products that can dry or irritate your skin, such as rough skin cleansers, soaps, or products that contain alcohol.

When Not To Use

This medicine is not right for everyone. Do not use it if you had an allergic reaction to clindamycin or tretinoin, you have Crohn disease or ulcerative colitis, or you had colitis from using an antibiotic.

Warnings

Tell your doctor if you are pregnant or breastfeeding, or you are planning to have general anesthesia for surgery.

This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

This medicine may cause a temporary change in skin color (lighter or darker).

Do not use this medicine to treat a skin problem your doctor has not examined.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Diarrhea that is watery or contains blood

Severe or ongoing skin redness, peeling, itching, blistering, crusting, or swelling

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

More side effects of this drug

Brand names include

Veltin, Ziana

There may be other brand names for this medicine.