Micromedex DrugNotes [Internet]. Truven Health Analytics; 1974-2016.

Oxycodone, Slow Release (By mouth)

Oxycodone Hydrochloride (ox-i-KOE-done hye-droe-KLOR-ide)

Treats moderate to severe pain. This medicine is a narcotic pain reliever.

Brand Name(s)

OxyCONTIN

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

This medicine is not right for everyone. Do not use it if you had an allergic reaction to oxycodone or other narcotic medicine, or if you have a stomach or bowel blockage.

How to Use This Medicine

Long Acting Tablet

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time. Swallow the extended-release tablet whole. Do not crush, break, or chew it. Do not take any tablet that is chipped or broken. Do not soak, lick, or wet the tablet before you place it in your mouth. Take 1 tablet at a time with enough water to swallow it completely. This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one. Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Ask your pharmacist about the best way to dispose of medicine you do not use.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Some foods and medicines can affect how oxycodone works. Tell your doctor if you are using any of the following:

Carbamazepine, erythromycin, ketoconazole, phenytoin, rifampin, ritonavir Diuretic (water pill) Phenothiazine medicine (including chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine) Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer. Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, breathing problems or lung disease (such as asthma or COPD), low blood pressure, digestion problems, an enlarged prostate, gallbladder disease, pancreas disease, or trouble swallowing or urinating. Tell your doctor if you have a history of head injury, brain tumor, depression, seizures, or alcohol or drug addiction. This medicine may cause the following problems:

High risk of overdose, which can lead to death Respiratory depression (serious breathing problem that can be life-threatening) This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working. Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely. This medicine may make you dizzy, drowsy, or faint. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully. This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation. Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing Blue lips, fingernails, or skin Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures Lightheadedness, dizziness, fainting Severe constipation, stomach pain, or vomiting Trouble breathing or slow breathing

If you notice these less serious side effects, talk with your doctor:

Headache Mild constipation, nausea, or vomiting Mild sleepiness or tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.