Naloxegol (By mouth)

nal-OX-ee-gol

Treats constipation caused by narcotic pain medicine.

Drug classes

Gastrointestinal Agent (About this – PubMed Health)

Uses

Uses of This Medicine

Naloxegol is used to treat constipation that is caused by opioids (narcotic pain medicines), in adults with long-lasting pain that is not caused by cancer.

This medicine is available only with your doctor’s prescription.

Other uses (PubMed Health)

How To Use

Tablet

Your doctor will tell you how much medicine to use. Do not use more than directed. Stop taking this medicine if you stop taking narcotic pain medicines.

Take this medicine on an empty stomach at least 1 hour before the first meal of the day or 2 hours after a meal.

Swallow the tablet whole. Do not crush, break, or chew it.

This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Do not use this medicine together with clarithromycin, itraconazole, or ketoconazole.

Some medicines and foods can affect how naloxegol works. Tell your doctor if you are using any of the following:

Carbamazepine Diltiazem Erythromycin Methadone Rifampin St John’s wort Verapamil

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

When Not To Use

This medicine is not right for everyone. Do not use it if you had an allergic reaction to naloxegol, or if you have a history of bowel blockage.

Warnings

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney or liver disease. Tell him if you have any stomach or bowel problems, including Crohn disease, Ogilvie syndrome, diverticulitis, or stomach or bowel cancer.

This medicine may cause a tear in your stomach or bowels.

Stop taking other laxatives before you start treatment with this medicine.

Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible side effects

Summary More details

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Chills, diarrhea, sweating, stomach pain, anxiety, irritability, yawning

Severe abdominal pain

If you notice other side effects that you think are caused by this medicine, tell your doctor.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

More side effects of this drug

Brand names include

Movantik

There may be other brand names for this medicine.