Carbidopa/Levodopa (By mouth)
Treats symptoms of Parkinson disease.
Antiparkinsonian (About this – PubMed Health)
Uses of This Medicine
Carbidopa and levodopa combination is used to treat Parkinson’s disease, sometimes called shaking palsy or paralysis agitans. Parkinson’s disease is a disorder of the central nervous system (brain and spinal cord).
Dopamine is a naturally occurring substance in the brain that helps provide control of movement and activities such as walking and talking. In patients with Parkinson’s disease, there is not enough dopamine in some parts of the brain. Levodopa enters the brain and helps replace the missing dopamine, which allows people to function better. By increasing the amount of dopamine in the brain, levodopa helps control symptoms and helps you to perform daily activities such as dressing, walking, and handling utensils.
This medicine is available only with your doctor’s prescription.
Other uses (PubMed Health)
How To Use
Long Acting Capsule, Tablet, Dissolving Tablet, Long Acting Tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Disintegrating tablet: Make sure your hands are dry before you handle the tablet. Do not remove the tablet from the bottle until you are ready to take it. Place the tablet on top of your tongue, where it will melt quickly.
Extended-release capsule or sustained-release tablet: Swallow the capsule or tablet whole. Do not crush, break, or chew it.
If you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Do not use this medicine if you have used an MAO inhibitor (MAOI) within the past 14 days.
Some foods and medicines can affect how carbidopa/levodopa works. Tell your doctor if you are using any of the following:Isoniazid, metoclopramide, papaverine, phenytoin, reserpine, risperidone, tetrabenazine A phenothiazine medicine (such as chlorpromazine, perphenazine, promethazine, prochlorperazine, thioridazine) Blood pressure medicine Medicine to treat depression or mental illness
When Not To Use
Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, endocrine problems, lung or breathing problems (such as asthma), a sleep disorder, heart or blood vessel problems, heart rhythm problems, or a history of heart attack. Tell your doctor if you have wide-angle glaucoma, phenylketonuria (PKU), or a history of stomach ulcer or mental illness.
This medicine may cause the following problems:Dyskinesia (trouble controlling movements) An increased risk for skin cancer Unusual changes in thoughts or behavior, such as the urge to gamble or an increased sex drive
This medicine may make you dizzy or drowsy, or even cause you to fall asleep without warning. This could happen while you are driving, eating, or talking. Tell your doctor right away if this happens. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
If you are already taking levodopa, stop taking it at least 12 hours before starting treatment with carbidopa/levodopa combination.
Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible side effects
Summary More details
Call your doctor right away if you notice any of these side effects:
Chest pain, trouble breathing, fast or uneven heartbeat
Compulsive behavior or intense urges you cannot control
Falling asleep in the middle of an activity
Jerky muscle movement you cannot control (often in your face, tongue, or jaw)
Unusual behavior, mood changes, seeing or hearing things that are not there, or thoughts of hurting yourself
If you notice these less serious side effects, talk with your doctor:
Drowsiness or sleepiness
Headache, trouble sleeping
Lightheadedness, dizziness, or fainting
Pink or red urine, dark sweat or saliva, or heavy sweating
If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
More side effects of this drug
Brand names include
Parcopa, Rytary, Sinemet 10-100, Sinemet 100/10, Sinemet 100/25, Sinemet 25-100, Sinemet 25-250, Sinemet 250/25, Sinemet CR, Sinemet CR 100/25, Sinemet CR 200/50
There may be other brand names for this medicine.